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Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the action of GTF3C3.
|Sequence:||1; NC_000001.11 (161120974..161132783, complement)|
Widely expressed with highest levels in testis.
Cytoplasm. Nucleus, nucleolus. Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells.