Beta-defensin 126 Antibodies

AND DEFB126 ELISA kits, Beta-defensin 126 Proteins

Many biological assays use antibodies to detect Beta-defensin 126, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beta-defensin 126 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beta-defensin 126 antibodies...

We validate the specificity of these antibodies to Beta-defensin 126 by testing them on tissues known to express DEFB126 positively and negatively. Browse below to find the DEFB126 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DEFB126 Infographic by Boster Bio

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DEFB126 (NM_030931) Human Over-expression Lysate

Human

$628
Cat # LS081623
20 µg, 100 µg

DEFB126 Overview

Facts about Beta-defensin 126.

DEFB126 3D structure. Source: alphafold

Beta-defensin 126 (DEFB126)

Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm defense against immunodetection; both acts are most likely implicating the negative surface charge supplied by its O-linked oligosaccharides in the sperm glycocalyx.

Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation via an altitude of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity).

Gene Information

Human
Gene Name:	DEFB126
Uniprot:	Q9BYW3
Entrez:	81623

Family

Belongs to:

beta-defensin family

Alternative Names

Beta-defensin 126

Molecular Weight

Mass (kDA):
12.174 kDA

Genomic Context


Human

Location:	20p13
Sequence:	20; NC_000020.11 (142590..145751)

Tissue Specificity

High-level and epididymis-specific expression. Expression is down-regulated in infertile men.

Subcellular Localizations

Secreted. Secreted by epididymal cells and is absorbed to the surface of sperm during transit through the epididymis (By similarity). Mainly located on the sperm acrosome.

PTMs

Cleavage on pair of basic residues

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DEFB126

References

PMID: 10491631 by Perry A.C.F., et al. The novel epididymal secretory protein ESP13.2 in Macaca fascicularis.

PMID: 12620395 by Rodriguez-Jimenez F.-J., et al. Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.