DnaJ homolog subfamily B member 14 (Dnajb14)

Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and encourage unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by discovering HSPA8/Hsc70's ATPase and polypeptide-binding activities.

Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the procedure for oligomerization of channel subunits is independent of HSPA8/Hsc70.