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Dock8 Antibodies
AND Dock8 ELISA kits, Dock8 Proteins
Many biological assays use antibodies to detect Dock8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dock8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dock8 antibodies...
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Dock8 Infographic by Boster Bio
All Dock8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, WB
$523
Cat # M01771-1
100 µl
Cat # M01771-1
100 µl
Human, Mouse, Rat
Flow Cytometry, WB
$523
Cat # M01771-2
100 µl
Cat # M01771-2
100 µl
Human, Mouse, Rat
IHC, WB
$523
Cat # M01771
100 µl
Cat # M01771
100 µl
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01771-1
100 μg/vial
Cat # A01771-1
100 μg/vial
Dock8 Overview
Facts about Dedicator of cytokinesis protein 8.
Dedicator of cytokinesis protein 8 (Dock8)
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune reactions, required for interstitial dendritic cell (DC) migration from locally activating CDC42 in the leading edge membrane of DC (PubMed:22461490, PubMed:25713392).
Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and potentially regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Dock8 |
| Uniprot: | Q8C147 |
| Entrez: | 76088 |
Family
| Belongs to: |
|---|
| DOCK family |
Alternative Names
dedicator of cytokinesis 8; FLJ00026; FLJ00346
Molecular Weight
Mass (kDA):
238.978 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 19|19 B |
| Sequence: | 19; |
Tissue Specificity
Expressed in T cells (PubMed:28028151). Expressed in bone marrow-derived dendritic cells (PubMed:25713392).
Diseases
- Immunologic Deficiency Syndromes
- Infective Disorder
- Job's Syndrome
- Virus Diseases
- Malignant Neoplasms
- Primary Immune Deficiency Disorder
- Congenital Combined Immunodeficiency
- Lymphopenia
- Eczema
- Dermatitis, Atopic
- Dermatitis
- Neoplasms
- Carcinoma
Pathways
- Cytokinesis
- Pathogenesis
- Immune Response
- Cell Migration
- Dna Methylation
- Methylation
- Cell Division
- Cell Adhesion
- Histone Deacetylation
- Cell Activation
- Cell-cell Signaling
- Cell Proliferation
- Anaphylaxis
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Dock8
bosterbio.com/bosterbio-gene-info-cards/Dock8
References
PMID: 25713392 by Krishnaswamy J.K., et al. Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
PMID: 28028151 by Xu X., et al. LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.