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- Table of Contents
Facts about Dual specificity protein phosphatase 7.
In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complicated in oocytes, likely by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity).
Human | |
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Gene Name: | DUSP7 |
Uniprot: | Q16829 |
Entrez: | 1849 |
Belongs to: |
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protein-tyrosine phosphatase family |
DKFZp586F2224; dual specificity phosphatase 7; Dual specificity protein phosphatase PYST2; dual-specificity phosphatase-7; EC 3.1.3.16; EC 3.1.3.48; MKPX; MKP-X; PYST2dual specificity protein phosphatase 7
Mass (kDA):
44.957 kDA
Human | |
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Location: | 3p21.2 |
Sequence: | 3; NC_000003.12 (52048919..52056571, complement) |
Strongly expressed in liver (PubMed:8670865). Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells (PubMed:14576828).
Cytoplasm.
PMID: 9788880 by Dowd S., et al. Isolation of the human genes encoding the Pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual- specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.
PMID: 14603440 by Levy-Nissenbaum O., et al. Characterization of the dual-specificity phosphatase PYST2 and its transcripts.