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EHD2 Antibodies
AND EHD2 ELISA kits, EHD2 Proteins
Many biological assays use antibodies to detect EHD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EHD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EHD2 antibodies...
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EHD2 Overview
Facts about EH domain-containing protein 2.
EH domain-containing protein 2 (EHD2)
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914).
Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes.
Gene Information
| Human | |
|---|---|
| Gene Name: | EHD2 |
| Uniprot: | Q9NZN4 |
| Entrez: | 30846 |
Family
| Belongs to: |
|---|
| TRAFAC class dynamin-like GTPase superfamily |
Alternative Names
EH domain containing 2; EH domain-containing protein 2; EH-domain containing 2; FLJ96617; PAST homolog 2; PAST2
Molecular Weight
Mass (kDA):
61.161 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (47713422..47743134) |
Tissue Specificity
Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle.
Subcellular Localizations
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, caveola; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes.
Diseases
- Neoplasms
- Glioma
- Cholera
- Malignant Neoplasms
- Stomach Neoplasms
- Muscle Injury
- Embryonal Carcinoma
- Infarction
- Malignant Paraganglionic Neoplasm
- Oligodendroglioma
- Mixed Oligodendroglioma-astrocytoma
- Tissue Adhesions
- Fibrolamellar Carcinoma
Pathways
- Endocytosis
- Endocytic Recycling
- Localization
- Transport
- Clathrin-mediated Endocytosis
- Defense Response
- Myoblast Fusion
- Cell Adhesion
- Hexose Transport
- Gene Silencing
- Protein Targeting
- Mitosis
- Dna Repair
PTMs
- Phosphorylation
- Sumoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EHD2
bosterbio.com/bosterbio-gene-info-cards/EHD2
References
PMID: 10673336 by Pohl U., et al. EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.
PMID: 15242332 by Aboulaich N., et al. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.