Eukaryotic translation initiation factor 3 subunit L (EIF3L)
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC).
The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).
|eIF-3 subunit L family|
eIEF associated protein HSPC021; EIF3EIP; eIF3l; EIF3S11; EIF3S6IP; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; Eukaryotic translation initiation factor 3 subunit E-interacting protein; eukaryotic translation initiation factor 3 subunit L; eukaryotic translation initiation factor 3, subunit 6 interacting protein; eukaryotic translation initiation factor 3, subunit L; HSPC021; HSPC025; MSTP005; subunit E interacting protein
|Sequence:||22; NC_000022.11 (37848868..37889407)|
- Cell Invasion
- Cell Transformation, Neoplastic
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Hepatitis C
- Cell Proliferation
- Cell Growth
- Core ESC-Like Genes
- Stem Cell Markers