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- Table of Contents
Facts about Eukaryotic translation initiation factor 3 subunit L.
The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).
Human | |
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Gene Name: | EIF3L |
Uniprot: | Q9Y262 |
Entrez: | 51386 |
Belongs to: |
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eIF-3 subunit L family |
eIEF associated protein HSPC021; EIF3EIP; eIF3l; EIF3S11; EIF3S6IP; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; Eukaryotic translation initiation factor 3 subunit E-interacting protein; eukaryotic translation initiation factor 3 subunit L; eukaryotic translation initiation factor 3, subunit 6 interacting protein; eukaryotic translation initiation factor 3, subunit L; HSPC021; HSPC025; MSTP005; subunit E interacting protein
Mass (kDA):
66.727 kDA
Human | |
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Location: | 22q13.1 |
Sequence: | 22; NC_000022.11 (37848868..37889407) |
Cytoplasm.
PMID: 11590142 by Morris-Desbois C., et al. The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3.
PMID: 12393749 by Yuan X., et al. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.