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- Table of Contents
Facts about Eukaryotic translation initiation factor 5B.
GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a necessity to form elongation-competent ribosomes.
Human | |
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Gene Name: | EIF5B |
Uniprot: | O60841 |
Entrez: | 9669 |
Belongs to: |
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No superfamily |
DKFZp434I036; eukaryotic translation initiation factor 5B; FLJ10524; IF2Translation initiation factor IF-2; KIAA0741eIF-5B; translation initiation factor IF2
Mass (kDA):
138.827 kDA
Human | |
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Location: | 2q11.2 |
Sequence: | 2; NC_000002.12 (99337389..99401326) |
Cytoplasm.
PMID: 10432305 by Wilson S.A., et al. Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2 and its interaction with HIV-1 matrix.
PMID: 10200264 by Lee J.H., et al. Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2.