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ENOX1 Antibodies
AND ENOX1 ELISA kits, ENOX1 Proteins
Many biological assays use antibodies to detect ENOX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ENOX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ENOX1 antibodies...
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ENOX1 Infographic by Boster Bio
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ENOX1 Overview
Facts about Ecto-NOX disulfide-thiol exchanger 1.
Ecto-NOX disulfide-thiol exchanger 1 (ENOX1)
Probably functions as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H through hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase action which might control physical membrane displacements associated with vesicle budding or cell enlargement.
The activities oscillate with a period length of 24 minutes and play a role in charge of the ultradian cellular biological clock. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ENOX1 |
| Uniprot: | Q8TC92 |
| Entrez: | 55068 |
Family
| Belongs to: |
|---|
| ENOX family |
Alternative Names
candidate growth-related and time keeping constitutive hydroquinone (NADH)oxidase; Candidate growth-related and time keeping constitutive hydroquinone [NADH]oxidase; cCNOXConstitutive Ecto-NOX; Cell proliferation-inducing gene 38 protein; cNOX; CNOXbA64J21.1; ecto-NOX disulfide-thiol exchanger 1; FLJ10094; PIG38; proliferation-inducing protein 38
Molecular Weight
Mass (kDA):
73.348 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q14.11 |
| Sequence: | 13; NC_000013.11 (43213130..43786976, complement) |
Tissue Specificity
Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells.
Subcellular Localizations
Cell membrane. Secreted, extracellular space. Extracellular and plasma membrane-associated.
Diseases
- Malignant Neoplasms
- Neoplasms
- Uterine Cervical Neoplasm
- Malignant Neoplasm Of Prostate
- Myasthenias
- Neoplasm Metastasis
- Lung Neoplasms
- Melanoma
- Colonic Neoplasms
- Autoimmune Diseases
- Cardiac Fibrillation
- Carcinogenesis
Interacting Proteins
- GORASP2
- LNX1
- SDCBP
- TRIM43
- ZMYND19
Pathways
- Transport
- Cell Migration
- Electron Transport
- Endothelial Cell Migration
- Nadh Oxidation
- Endothelial Cell Morphogenesis
- Angiogenesis
PTMs
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ENOX1
bosterbio.com/bosterbio-gene-info-cards/ENOX1
References
PMID: 19055324 by Jiang Z., et al. Molecular cloning and characterization of a candidate human growth- related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase.
PMID: 11360993 by Sedlak D., et al. A drug-unresponsive and protease-resistant CNOX protein from human sera.