Exonuclease 3'-5' domain-containing protein 2 (EXD2)

Exonuclease needed for double-strand breaks resection and efficient homologous recombination. Plays a vital role in controlling the first steps of chromosomal fracture repair, it's recruited to chromatin in a damage-dependent fashion and functionally interacts with the MRN complex to accelerate resection via its 3'-5' exonuclease activity, which effectively processes double-stranded DNA substrates containing nicks.

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