EXD2 Antibodies

AND EXD2 ELISA kits, EXD2 Proteins

Many biological assays use antibodies to detect EXD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EXD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EXD2 antibodies...

We validate the specificity of these antibodies to EXD2 by testing them on tissues known to express EXD2 positively and negatively. Browse below to find the EXD2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EXD2 Infographic by Boster Bio

All EXD2 Products

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Anti-EXD2 Antibody

Human, Mouse, Rat

ELISA, IP, IF, IHC, ICC, WB

$370
Cat # A12093-2
100 μl/vial

EXD2 Overview

Facts about Exonuclease 3'-5' domain-containing protein 2.

EXD2 3D structure. Source: alphafold

Exonuclease 3'-5' domain-containing protein 2 (EXD2)

Exonuclease needed for double-strand breaks resection and efficient homologous recombination. Plays a vital role in controlling the first steps of chromosomal fracture repair, it's recruited to chromatin in a damage-dependent fashion and functionally interacts with the MRN complex to accelerate resection via its 3'-5' exonuclease activity, which effectively processes double-stranded DNA substrates containing nicks.

Gene Information

Human
Gene Name:	EXD2
Uniprot:	Q9NVH0
Entrez:	55218

Family

Belongs to:

EXD2 family

Alternative Names

C14orf114; chromosome 14 open reading frame 114; DKFZp781A0133; DKFZp781L15100; EXDL2; exonuclease 3'-5' domain containing 2; exonuclease 3'-5' domain-containing protein 2; exonuclease 3'-5' domain-like 2; Exonuclease 3'-5' domain-like-containing protein 2; FLJ10738

Molecular Weight

Mass (kDA):
70.353 kDA

Genomic Context


Human

Location:	14q24.1
Sequence:	14; NC_000014.9 (69191477..69244020)

Subcellular Localizations

Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion matrix. Nucleus. Chromosome. Mainly localizes to the mitochondrial outer membrane (PubMed:29599527, PubMed:31127291). May translocate to the nucleus in response to DNA damage; however mechanism that explain nuclear localization are unknown and require experimental evidences (PubMed:26807646). Recruited to replication forks following replication stress (PubMed:31255466).

Interacting Proteins

RBBP8

Pathways

Localization
Rna Localization

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EXD2

References

PMID: 20603073 by Smogorzewska A., et al. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

PMID: 26807646 by Broderick R., et al. EXD2 promotes homologous recombination by facilitating DNA end resection.