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Eyes absent homolog 2 Antibodies
AND EYA2 ELISA kits, Eyes absent homolog 2 Proteins
Many biological assays use antibodies to detect Eyes absent homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Eyes absent homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Eyes absent homolog 2 antibodies...
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EYA2 Overview
Facts about Eyes absent homolog 2.
Eyes absent homolog 2 (EYA2)
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and likely also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1.
'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | EYA2 |
| Uniprot: | O00167 |
| Entrez: | 2139 |
Family
| Belongs to: |
|---|
| HAD-like hydrolase superfamily |
Alternative Names
EAB1EC 3.1.3.48; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); eyes absent homolog 2; MGC10614
Molecular Weight
Mass (kDA):
59.232 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.12 |
| Sequence: | 20; NC_000020.11 (46894624..47188844) |
Tissue Specificity
Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
Subcellular Localizations
Cytoplasm. Nucleus. Retained in the cytoplasm via interaction with GNAZ and GNAI2 (PubMed:10906137). Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus (PubMed:10906137, PubMed:12500905).
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Crest Syndrome
- Branchio-oto-renal Syndrome
- Malignant Neoplasm Of Breast
- Adenocarcinoma
- Hypertrophy
- Cardiac Hypertrophy
- Sarcoma
- Fibrosis
- Scleral Diseases
Interacting Proteins
- SIX1
Pathways
- Eye Development
- Cell Death
- Neurogenesis
- Somitogenesis
- Localization
- Limb Development
- Cell Differentiation
- Cell Proliferation
- Methylation
- Pathogenesis
- Rna Interference
- Cell Adhesion
- Cell Activation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EYA2
bosterbio.com/bosterbio-gene-info-cards/EYA2
References
PMID: 9195991 by Duncan M.K., et al. Eyes absent: a gene family found in several metazoan phyla.
PMID: 9020840 by Abdelhak S., et al. A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.