- Table of Content
'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis.
|HAD-like hydrolase superfamily|
|Sequence:||20; NC_000020.11 (46894624..47188844)|
Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
Cytoplasm. Nucleus. Retained in the cytoplasm via interaction with GNAZ and GNAI2 (PubMed:10906137). Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus (PubMed:10906137, PubMed:12500905).