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ERCC8 Antibodies
AND ERCC8 ELISA kits, ERCC8 Proteins
Many biological assays use antibodies to detect ERCC8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERCC8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERCC8 antibodies...
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ERCC8 Infographic by Boster Bio
All ERCC8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M04153
100 µl
Cat # M04153
100 µl
ERCC8 Overview
Facts about DNA excision repair protein ERCC-8.
DNA excision repair protein ERCC-8 (ERCC8)
Substrate-recognition part of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complicated ) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent way; ERCC6 degradation is important for the recovery of RNA synthesis following transcription-coupled repair.
It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coupled repair complex which eliminates RNA polymerase II-blocking lesions from the transcribed strand of active genes. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ERCC8 |
| Uniprot: | Q13216 |
| Entrez: | 1161 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CKN1DNA excision repair protein ERCC-8; Cockayne syndrome 1 (classical); Cockayne syndrome WD repeat protein CSA; CSACockayne syndrome WD-repeat protein CSA; excision repair cross-complementing rodent repair deficiency, complementationgroup 8
Molecular Weight
Mass (kDA):
44.055 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q12.1 |
| Sequence: | 5; NC_000005.10 (60866454..60945078, complement) |
Subcellular Localizations
Nucleus. Nucleus matrix. UV-induced translocation to the nuclear matrix is dependent on ERCC6.
Diseases
- Cockayne Syndrome
- Xeroderma Pigmentosum
- Hereditary Diseases
- Xeroderma
- Malignant Neoplasms
- Cachexia
- Microcephaly
- Neurodegenerative Disorders
- Premature Aging Syndrome
- Dwarfism
- Atrophy
Interacting Proteins
- ERCC6
- XAB2
Pathways
- Dna Repair
- Aging
- Hypersensitivity
- Nucleotide-excision Repair
- Mismatch Repair
- Dna Replication
- Response To Uv
- Cell Cycle
- Pathogenesis
- Rna Interference
- Oxidative Phosphorylation
- Cell Cycle Arrest
- Response To Oxidative Stress
PTMs
- Phosphorylation
Research Areas
- Cancer
- DNA Repair
- Nucleotide Excision Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERCC8
bosterbio.com/bosterbio-gene-info-cards/ERCC8
References
PMID: 7664335 by Henning K.A., et al. The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.
PMID: 12732143 by Groisman R., et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.