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- Table of Contents
F2RL1 Antibodies
AND F2RL1 ELISA kits, F2RL1 Proteins
Many biological assays use antibodies to detect F2RL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with F2RL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop F2RL1 antibodies...
Designing a Western blot for F2RL1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the F2RL1 Western Blot GuideF2RL1 Infographic by Boster Bio
All F2RL1 Products
Product
Figures
Specificity
Applications
Price
Anti-PAR2 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01081
100 μl/vial
Cat # M01081
100 μl/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01081-3
100 μg
Cat # M01081-3
100 μg
Human, Mouse, Rat
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01081-2
100 μg
Cat # M01081-2
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01081-1
100 μg
Cat # M01081-1
100 μg
F2RL1 Overview
Facts about Proteinase-activated receptor 2.
Proteinase-activated receptor 2 (F2RL1)
Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways such as phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455).
May also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory reactions and regulation of innate and adaptive immunity, and functions as a sensor for proteolytic enzymes generated during infection.
Gene Information
| Human | |
|---|---|
| Gene Name: | F2RL1 |
| Uniprot: | P55085 |
| Entrez: | 2150 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
CFIIRL1; coagulation factor II (thrombin) receptor-like 1; Coagulation factor II receptor-like 1; F2RL1; GPCR11; GPR11protease-activated receptor 2; G-protein coupled receptor 11; PAR2; PAR-2; PAR2G protein-coupled receptor-11; proteinase-activated receptor 2; proteinase-activated receptor-2; Thrombin receptor-like 1
Molecular Weight
Mass (kDA):
44.126 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q13.3 |
| Sequence: | 5; NC_000005.10 (76819030..76835315) |
Tissue Specificity
Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon (PubMed:7556175, PubMed:8615752). Moderate expression is detected in many organs, but none in brain or skeletal muscle (PubMed:7556175, PubMed:8615752). Expressed in endothelial cells (PubMed:23202369).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Intestinal Diseases
- Obesity
- Radiation Injury
- Premature Obstetric Labor
- Cns Disorder
- Radiation Injuries, Experimental
- Inflammatory Bowel Diseases
- Autoimmune Diseases
- Insulin Resistance
- Ulcerative Colitis
- Ulcer
- Hypertensive Disease
- Fibrosis
Interacting Proteins
- Arrb1
- ATP2A2
- CBL
- COPS5
- F3
- HSPA1B
- PRNP
- TMED2
Pathways
- Coagulation
- Glycosylation
- Immune Response
- Angiogenesis
- Rna Interference
- Localization
PTMs
- Phosphorylation
Research Areas
- GPCR
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/F2RL1
bosterbio.com/bosterbio-gene-info-cards/F2RL1
References
PMID: 7556175 by Nystedt S., et al. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2.
PMID: 8615752 by Boehm S.K., et al. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2.
1 Publications of Boster F2RL1 Antibodies & ELISA Kits
- PubMed ID: 27906434, D. QUANJUN, Z. QINGYU, Z. QILIANG, X. LIQUN, C. JINMEI, L. ZIQUAN, H. SHIKE Eur ...
*More publications can be found for each product on its corresponding product page