Free fatty acid receptor 1 (FFAR1)

G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an essential role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and might also improve the secretion of glucagon-like peptide 1 (GLP-1).

May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding results in a conformation change that triggers signaling through G-proteins that activate phospholipase C, resulting in an increase of the intracellular calcium concentration.