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We validate the specificity of these antibodies to FNDC5 by testing them on tissues known to express FNDC5 positively and negatively. Browse below to find the FNDC5 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.
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Facts about Fibronectin type III domain-containing protein 5.
fibronectin type III domain containing 5; fibronectin type III domain-containing protein 5; FNDC5; FRCP2; FRCP2Fibronectin type III repeat-containing protein 2; Irisin
|Sequence:||1; NC_000001.11 (32862268..32872484, complement)|
Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.
Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Imported in peroxisomes through the PEX5 receptor pathway.; [Irisin]: Secreted. Detected in the blood of individuals subjected to endurance exercise.
There are many uses for the FNDC5 marker, including cancer research, gene mapping, and cell biology. Read on for some of these applications. This article will cover the Specificity, Applications, and Allelic Differences of the FNDC5 marker. This article will provide you with a detailed understanding of this unique marker and how you can use it effectively in your research. Also, learn about Boster's process for developing primary antibodies.
FNDC5 is a single-pass type I membrane protein that encodes the prohormone irisin. Irisin is produced by post-translational processing of the FNDC5 gene. The resulting protein has a signal peptide, a single fibronectin type III domain, and a C-terminal hydrophobic domain. It is anchored to the cell membrane.
The FNDC5 gene is regulated by several factors, including PGC1-a. Multiple myogenic factors activate FNDC5 but do not cooperate with PGC1-a. This suggests that FNDC5 expression is regulated by distinct transcriptional machineries. In addition, it is associated with muscle-adipose-bone connectivity. Although its regulation is largely unclear, it may be involved in secondary processes.
Research on this marker is ongoing, but it has therapeutic potential. It is known to trigger the differentiation of neural stem cells, which may help treat many neurodegenerative diseases. There are several different types of FNDC5 that are associated with ABI. The markers irisin and FNDC5 work together to promote neural cell survival, differentiation, and self-renewal. This suggests that the two markers may be related.
This study describes the expression and secretion of the FNDC5/irisin marker in differentiated C3h20T1/2 murine mesenchimal stem cells. This biomarker has been implicated in inflammation. It can be used in the diagnosis of HCC. The authors of the study declare that they have no competing interests. Although the study does not address the sensitivity and specificity of this biomarker, it may be a useful tool for further research.
Studies using FNDC5/irisin as a diagnostic marker have shown its sensitivity and specificity in a range of human diseases. The FNDC5/irisin gene is essential for secretion of irisin. Hence, serum FNDC5/irisin levels have been found in patients with diabetes, type 2 diabetes and chronic kidney disease. Other studies have shown that serum levels of FNDC5/irisin may also be useful in cancer diagnosis.
While FNDC5/irisin has positive associations with cognitive impairment, it is not specific enough to predict whether someone has dementia. In fact, it may have a more positive correlation with other cognitive diseases such as heart failure, stroke, Parkinson's disease, or Alzheimer's disease. In addition, there are many other studies that support the benefits of FNDC5/irisin for detecting dementia. For now, however, this marker cannot be used to diagnose dementia.
The FNDC5 marker is an important candidate for metabolic homeostasis. Several studies have demonstrated that altered expression of FNDC5 is associated with metabolic disorders, including obesity and type 2 diabetes. Further studies are needed to identify the exact roles of FNDC5 in different body systems, and to determine whether it plays a role in specific metabolic conditions. The FNDC5 gene has been discovered independently in 2002. It is expressed in a variety of tissues and has been implicated in adipocyte differentiation and metabolism.
The FNDC5 marker has shown potential therapeutic roles in cardiovascular and metabolic diseases. Overexpression of this protein in cardiac tissues protects cardiomyocytes from oxidative damage and attenuates cell apoptosis. It is also a promising candidate to combat DOX-induced cardiotoxicity. However, further studies are needed to confirm its potential in human clinical trials. Therefore, the FNDC5 marker is an important biomarker in a variety of settings.
This marker has been identified as a possible biomarker for metabolic diseases, including hypertension, diabetes, and metabolic syndrome. It was initially detected in the skeletal muscle of a patient with a toxic thyroid condition. In the future, this marker could be used to monitor metabolic status and detect diseases such as toxic thyroid goiter. These findings indicate that FNDC5 may be useful as a biomarker for metabolic monitoring.
In addition to its unique ability to detect bitter receptors, BitterDB provides several other methods for investigating the bitter world. Using different criteria, researchers can search for bitter molecules with the same structure, or they can blast them for the presence of specific receptors. Boster Bio is an antibody manufacturer specializing in high-specification WB/IHC compatible antibodies. In addition to their expertise in antibody development, BPS Bioscience has a history of working with recombinant DNA and cell lines and biochemical assays.
BDNF is a protein that can be measured by measuring pro-BDNF levels in the plasma. The Anti-BDNF Antibody Picoband(tm) from Boster Bio can detect BDNF levels in Human, Mouse and Rat cells. This kit is available in the catalog under the code PB9075. In addition to the BDNF antigen, this kit contains Trehalose, NaCl and Na2HPO4.
The results of the study showed that BDNF expression was significantly lower after a period of intense exercise, which is consistent with the decaying effect of acute metabolic stress. Moreover, the decline in BDNF expression was more pronounced in subjects with a higher level of expression pre-exercise than in those with a lower level of pre-exercise BDNF levels. Therefore, BDNF expression during exercise might be associated with increased metabolic sensitivity and stability, a result of the higher pre-exercise BDNF level.
BDNF promotes the survival and differentiation of select neuronal populations. In addition, BDNF regulates dendritic growth and contributes to the homeostatic regulation of intrinsic neuronal excitability. The biological effects of BDNF are diverse and applicable to any scientist from any country. Moreover, it is also affordable. If you are looking for a high-quality anti-BDNF antibody, then Boster should be your first choice.
The FNDC5 gene, also known as irisin, is a gene that controls the production of neurotrophins, including IL-6. The FNDC5 marker is a potential therapeutic target for neurodegenerative diseases. It has been shown to reduce the amount of oxidative stress that occurs in the brain, thus preventing lesion formation.
The FNDC5 gene is regulated by PGC-1a. Thus, FNDC5 is upregulated in the hippocampus in endurance exercise mice. Furthermore, forced expression of FNDC5 in primary cortical neurons increases Bdnf expression, whereas RNAi-mediated knockdown of FNDC5 reduces Bdnf expression. Moreover, peripheral delivery of FNDC5 via adenoviral vectors results in elevated blood irisin levels and increases Bdnf expression.
The FNDC5 marker is a polypeptide that promotes neuronal migration. Neurons in a culture medium containing FNDC5 express high levels of the Bdnf gene. Primary cortical neurons were treated with conditioned media derived from CHO cell lines overexpressing irisinFc or human Fc and total RNA was harvested the next day.
During brain development, the proliferative germinal zones play important roles in the production of appropriate numbers and classes of cells. Regulation of these zones is a major goal of developmental neuroscience. In this review, we will focus on neuronal migration and specifically cerebellar cell types. We will discuss the role of this marker in neuronal migration in the cerebellum. This review will discuss the molecular mechanism of cerebellar neuron migration and the potential therapeutic uses for the FNDC5 marker.
This marker was first used to identify projection neurons of the cerebellar nucleus. Using this marker, we found that projection neurons migrate radially towards the NTZ under the guidance of a neuronal cell marker, Diffusible Netrin. The Diffusible Netrin family is a family of secreted proteins that regulate neuronal migration. We also found that the Ptf1a promoter can distinguish inhibitory CN neurons from projection neurons.
*More publications can be found for each product on its corresponding product page