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fMet-Leu-Phe receptor Antibodies
AND FPR1 ELISA kits, fMet-Leu-Phe receptor Proteins
Many biological assays use antibodies to detect fMet-Leu-Phe receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with fMet-Leu-Phe receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop fMet-Leu-Phe receptor antibodies...
Designing a Western blot for fMet-Leu-Phe receptor? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FPR1 Western Blot GuideFPR1 Infographic by Boster Bio
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FPR1 Overview
Facts about fMet-Leu-Phe receptor.
fMet-Leu-Phe receptor (FPR1)
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are strong neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520).
This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456). .
Gene Information
| Human | |
|---|---|
| Gene Name: | FPR1 |
| Uniprot: | P21462 |
| Entrez: | 2357 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
fMet-Leu-Phe receptor; fMLF-R; fMLP receptor; FMLP; formyl peptide receptor 1; FPR1; FPRfMet-Leu-Phe receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor
Molecular Weight
Mass (kDA):
38.446 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.41 |
| Sequence: | 19; NC_000019.10 (51745172..51751878, complement) |
Tissue Specificity
Neutrophils.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Internalizes in presence of its ligand, TAFA4.
Diseases
- Inflammation
- Inflammatory Response
- Neoplasms
- Infective Disorder
- Alzheimer's Disease
- Periodontitis
- Malignant Neoplasms
- Cell Invasion
- Periodontitis, Juvenile
- Pertussis
- Arthritis
- Tissue Adhesions
- Bacterial Infections
Interacting Proteins
- GRK2
- MAPK13
Pathways
- Chemotaxis
- Mating
- Fertilization
- Localization
- Inflammatory Response
- Cell Migration
- Neutrophil Chemotaxis
- Cell Cycle
- Secretion
- Immune Response
- Cell Activation
- Neutrophil Activation
- Virulence
PTMs
- Phosphorylation
- Formylation
- Cleavage
Research Areas
- GPCR
- Immunology
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FPR1
bosterbio.com/bosterbio-gene-info-cards/FPR1
References
PMID: 2161213 by Boulay F., et al. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA.
PMID: 2176894 by Boulay F., et al. The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.