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fMet-Leu-Phe receptor Antibodies
AND FPR1 ELISA kits, fMet-Leu-Phe receptor Proteins
Many biological assays use antibodies to detect fMet-Leu-Phe receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with fMet-Leu-Phe receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop fMet-Leu-Phe receptor antibodies...
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FPR1 Overview
Facts about fMet-Leu-Phe receptor.
fMet-Leu-Phe receptor (FPR1)
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are strong neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520).
This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456). .
Gene Information
| Human | |
|---|---|
| Gene Name: | FPR1 |
| Uniprot: | P21462 |
| Entrez: | 2357 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
fMet-Leu-Phe receptor; fMLF-R; fMLP receptor; FMLP; formyl peptide receptor 1; FPR1; FPRfMet-Leu-Phe receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor
Molecular Weight
Mass (kDA):
38.446 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.41 |
| Sequence: | 19; NC_000019.10 (51745172..51751878, complement) |
Tissue Specificity
Neutrophils.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Internalizes in presence of its ligand, TAFA4.
Diseases
- Inflammation
- Inflammatory Response
- Neoplasms
- Infective Disorder
- Alzheimer's Disease
- Periodontitis
- Malignant Neoplasms
- Cell Invasion
- Periodontitis, Juvenile
- Pertussis
- Arthritis
- Tissue Adhesions
- Bacterial Infections
Interacting Proteins
- GRK2
- MAPK13
Pathways
- Chemotaxis
- Mating
- Fertilization
- Localization
- Inflammatory Response
- Cell Migration
- Neutrophil Chemotaxis
- Cell Cycle
- Secretion
- Immune Response
- Cell Activation
- Neutrophil Activation
- Virulence
PTMs
- Phosphorylation
- Formylation
- Cleavage
Research Areas
- GPCR
- Immunology
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FPR1
bosterbio.com/bosterbio-gene-info-cards/FPR1
References
PMID: 2161213 by Boulay F., et al. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA.
PMID: 2176894 by Boulay F., et al. The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.