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- Table of Contents
Facts about N-acetylgalactosamine-6-sulfatase.
Human | |
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Gene Name: | GALNS |
Uniprot: | P34059 |
Entrez: | 2588 |
Belongs to: |
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sulfatase family |
Chondroitinase; Chondroitinsulfatase; EC 3.1.6; EC 3.1.6.4; FLJ17434; FLJ42844; FLJ98217; GA6S; galactosamine (N-acetyl)-6-sulfate sulfatase; Galactose-6-Sulfate Sulfatase; GalNAc6S Sulfatase; GALNAC6S; GALNS; GAS; MPS4A; NAcetylgalactosamine6Sulfatase; N-Acetylgalactosamine-6-Sulfatase; N-acetylgalactosamine-6-sulfate sulfatase
Mass (kDA):
58.026 kDA
Human | |
---|---|
Location: | 16q24.3 |
Sequence: | 16; NC_000016.10 (88813734..88856966, complement) |
Lysosome.
As an industry leader in high affinity primary antibodies, Boster is a perfect choice for high-quality GALNS reagents. These antibodies are cited in scientific literature and have been validated by Western Blotting, Immunohistochemistry, and ELISA. You can learn more about Boster (the man behind high-affinity prima antibodies) and what projects he is working on.
Boster Bio provides a wide range solutions for researchers who are looking for high-affinity primary antibodies against GalNS. These antibodies can provide specificity in your studies, making it possible to discover the most accurate antibody specificity. High-affinity antibodies are particularly useful for cancer research, since they can target specific cancer cell markers in their studies.
The GALNSMarker has emerged as a promising marker for lung cancer. Because of its potential to detect multiple types of cancer, the marker has been identified for further investigation in combination with PAEP, a biomarker already found in lung cancer. There are still many questions. In the meantime, this marker is proving its worth by providing new insights in multiple cancer types. These are some of the projects currently being done with this biomarker.
GALNS has been identified as a biomarker candidate. GALNS was identified in a cell-line with low metastasis possibility by proteomics analysis. Although the gene's expression has not been determined in all tissues, mutations in GALNS have been linked with MPS IV A, Morquio Syndrome, and many other cancers.
PMID: 1755850 by Tomatsu S., et al. Morquio disease: isolation, characterization and expression of full- length cDNA for human N-acetylgalactosamine-6-sulfate sulfatase.
PMID: 8001980 by Morris C.P., et al. Morquio A syndrome: cloning, sequence, and structure of the human N- acetylgalactosamine 6-sulfatase (GALNS) gene.