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- Table of Contents
11 Q&As
Facts about Growth arrest-specific protein 1.
Prevents cycling of normal and transformed cells. .
Human | |
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Gene Name: | GAS1 |
Uniprot: | P54826 |
Entrez: | 2619 |
Belongs to: |
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No superfamily |
Gas1; GAS-1; growth arrest-specific 1; Growth arrest-specific gene-1; growth arrest-specific protein 1
Mass (kDA):
35.693 kDA
Human | |
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Location: | 9q21.33 |
Sequence: | 9; NC_000009.12 (86944362..86947506, complement) |
Cell membrane; Lipid-anchor, GPI-anchor.
You're probably familiar with the Anti-GAS1 and Boster Bio Markers. But did you know that this mouse could be a great tool for your research? You're in the right place. This Boster Bio review will give you the scoop on this marker, including how it can help your research, and the advantages it has for you. Here are some benefits of this mouse:
You can use the boster bio anti–GAS1 antibody to test for the GAS1 mark in your research. Boster Bio has developed its antibodies using antibodies made from rabbits and mice. These antibodies react with GAS1 from many animal samples. The Boster bio anti-GAS1 antibody is available in both mouse and human forms. These antibodies can be used in a variety of biological assays.
Gas1 is an essential gene for the development of long bones, and overexpression of Gas1 is associated with reduced body size and a smaller eye. Gas1 is expressed in the ventral neural protogenitor domain together with the related gene Nkx6.1. This gene can be expressed by both ectopic and non-ectopic cells. Gas1 is also highly expressed in neurons that express GFP or pCIR.
Gas1 promotes Shh signaling in its target cell. Shh can activate the expression of shag-binding membrane proteins such as Boc. Boc is a receptor for Shh during commissural axon guidance. Gas1 expression correlates with axonal direction. Gas1 deficient embryos have aberrant axonal projections that cause misdirection through the Isl1/2+ motor columns.
During neural tube patterning (Neural tube patterning), Gas1 is expressed within the ventral portion of the CNS. At E9.5, Gas1 expression overlaps the dorsal subset of Shh-responsive Nkx6.1+ cells. It is still restricted dorsally at E10.5, but there is a domain of expression in the commissural Axons that project ventrally from dorsal neural tubes.
FP specification is dependent on Gas1 expression. Reduced Shh dosage worsens the compromised specification for Gas1-/embryos. Further, Gas1-/ embryos show no FoxA2+ cells. Moreover, decreased Shh dose leads to increased FP expression, while gas1-/ embryos are completely absent of FoxA2+ cells. Interestingly, the increased expression of FoxA2 in the embryos of Gas1-/ mice is associated with craniofacial defects, limb defects, and axon guidance deficiencies.
The gas1 gene encodes the 45-kDa cellsurface protein that binds Shh at high affinity. It was initially identified as an antagonist to Shh-signaling. Studies of Gas1 expression in the tooth and somite revealed that the gene is important for the development of limbs and cerebellum. Mutant mice lacking high levels of gas1 expression have defects in their eyes, cerebellum, and legs. These defects are often associated with decreased Shh signaling.
GAS1 is involved with controlling cell growth, programmed cells death, and mouse developmental. However, there are no data to suggest that the gene is important for quiescence in adult tissues. Over-expressions in gas1 in cancer cells and tumors can lead to inhibition of cell growth. In addition, gas1 overexpression inhibits the proliferation of tumor cell and culturedfibroblast cells.
GAS1 markers are genes that are expressed in neurons and then released by cells. This gene may play an important role in the CNS's cellular signaling. Gas1 expression is decreased in mice that are homozygous or susceptible to disruption during embryonic growth. However, the mouse homozygous in GAS1 gene disruption suffers decreased viability and developmental problems.
PMID: 8127893 by del Sal G., et al. Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene.
*More publications can be found for each product on its corresponding product page