Gen1 Antibodies

AND Gen1 ELISA kits, Gen1 Proteins

Many biological assays use antibodies to detect Gen1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gen1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gen1 antibodies...

We validate the specificity of these antibodies to Gen1 by testing them on tissues known to express Gen1 positively and negatively. Browse below to find the Gen1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Gen1 Infographic by Boster Bio

All Gen1 Products

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Product

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Specificity

Applications

Price

Anti-GEN1 Antibody

Western blot analysis of extracts of various cell lines, using GEN1 antibody at 1:1000 dilution

Human, Mouse

$405
Cat # A06202
100ul

GEN1 (NM_182625) Human Over-expression Lysate

GEN1 Human Over-expression Lysates NM_001130009

Human

$960
Cat # LS348654
20 µg, 100 µg

Gen1 Overview

Facts about Flap endonuclease GEN homolog 1.

Flap endonuclease GEN homolog 1 (Gen1)

Endonuclease which resolves Holliday junctions (HJs) from the introduction of symmetrically related cuts throughout the intersection point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also called Holliday junctions, are formed through homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.

Cleaves HJs by a nick and counter-nick mechanism involving double coordinated incisions that lead to the formation of ligatable nicked duplex solutions. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid.

Gene Information

Mouse
Gene Name:	Gen1
Uniprot:	Q8BMI4
Entrez:	209334

Family

Belongs to:

XPG/RAD2 endonuclease family

Alternative Names

Flap endonuclease GEN homolog 1

Molecular Weight

Mass (kDA):
101.779 kDA

Genomic Context


Mouse

Location:	12\|12 A1.1
Sequence:	12;

Tissue Specificity

Expressed in bone marrow and testis and to a lesser extent in thymus, spleen, brain and colon.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Gen1

References

PMID: 27010503 by Braun J., et al. The GIY-YIG type endonuclease ankyrin repeat and LEM domain- containing protein 1 (ANKLE1) is dispensable for mouse hematopoiesis.