This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
GIT1 Antibodies
AND GIT1 ELISA kits, GIT1 Proteins
Many biological assays use antibodies to detect GIT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GIT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GIT1 antibodies...
Previous: SEPTIN9
Next: SLC27A6
GIT1 Infographic by Boster Bio
All GIT1 Products
Product
Figures
Specificity
Applications
Price
Anti-GIT1 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02140-3
100 μg/vial
Cat # A02140-3
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M02140-1
100 μl/vial
Cat # M02140-1
100 μl/vial
GIT1 Overview
Facts about ARF GTPase-activating protein GIT1.
ARF GTPase-activating protein GIT1 (GIT1)
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization.
Increases the rate of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes.
Gene Information
| Human | |
|---|---|
| Gene Name: | GIT1 |
| Uniprot: | Q9Y2X7 |
| Entrez: | 28964 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ARF GAP GIT1; ARF GTPase-activating protein GIT1; CAT1; CAT-1; Cool-associated and tyrosine-phosphorylated protein 1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase interactor 1; G protein-coupled receptor kinase-interactor 1; GIT1; GRK-interacting protein 1
Molecular Weight
Mass (kDA):
84.341 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q11.2 |
| Sequence: | 17; NC_000017.11 (29573475..29589648, complement) |
Subcellular Localizations
Cytoplasm. Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Tumor Angiogenesis
- Carcinoma
- Neoplasms
- Protrusion
- Nervousness
- Huntington Disease
- Cholangiocarcinoma
- Malignant Neoplasm Of Breast
- Ulcer
- Attention Deficit Hyperactivity Disorder
Interacting Proteins
- ARHGEF7
- BARD1
- CEP126
- CHD3
- GRK2
- HTT
- LRIF1
- PAK1
Pathways
- Cell Migration
- Localization
- Cell Motility
- Transport
- Endocytosis
- Angiogenesis
- Cell Adhesion
- Pathogenesis
- Exocytosis
- Receptor Internalization
- Rna Interference
- Cell Proliferation
- Translation
PTMs
- Phosphorylation
- Ribosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GIT1
bosterbio.com/bosterbio-gene-info-cards/GIT1
References
PMID: 10896954 by Premont R.T., et al. The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.
PMID: 9826657 by Premont R.T., et al. Beta2-adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
1 Publications of Boster GIT1 Antibodies & ELISA Kits
- PubMed ID: 10.1080/21655979.2021.1926201, Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardia...
*More publications can be found for each product on its corresponding product page