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- Table of Contents
Glutamine synthetase Antibodies
AND GLUL ELISA kits, Glutamine synthetase Proteins
Many biological assays use antibodies to detect Glutamine synthetase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Glutamine synthetase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Glutamine synthetase antibodies...
Designing a Western blot for Glutamine synthetase? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GLUL Western Blot GuideDesigning an IHC experiment for Glutamine synthetase? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the GLUL IHC GuideGLUL Infographic by Boster Bio
All GLUL Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03191-3
100 μg/vial
Cat # A03191-3
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$370
Cat # M03191
100 μl
Cat # M03191
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M03191-2
20μL, 40μL, 100μL, 200μL
Cat # M03191-2
20μL, 40μL, 100μL, 200μL
Human
$628
Cat # LS002752
20 µg, 100 µg
Cat # LS002752
20 µg, 100 µg
GLUL Overview
Facts about Glutamine synthetase.
Glutamine synthetase (GLUL)
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the mind, it regulates the amount of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it's one of the enzymes responsible for the removal of ammonia (By similarity).
Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: functions by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707).
Gene Information
| Human | |
|---|---|
| Gene Name: | GLUL |
| Uniprot: | P15104 |
| Entrez: | 2752 |
Family
| Belongs to: |
|---|
| glutamine synthetase family |
Alternative Names
cell proliferation-inducing protein 59; EC 4.1.1.15; EC 6.3.1.2; GLNSPIG59; Glutamate decarboxylase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase; Glutamate--ammonia ligase; glutamine synthase; glutamine synthetase; GS; PIG43; proliferation-inducing protein 43
Molecular Weight
Mass (kDA):
42.064 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q25.3 |
| Sequence: | 1; NC_000001.11 (182378093..182392206, complement) |
Tissue Specificity
Expressed in endothelial cells.
Subcellular Localizations
Cytoplasm, cytosol. Microsome. Mitochondrion. Cell membrane; Lipid-anchor. Mainly localizes in the cytosol, with a fraction associated with the cell membrane.
Diseases
- Liver Carcinoma
- Liver Neoplasms
- Carcinoma
- Neoplasms
- Adenoma
- Malignant Neoplasms
- Hemorrhage
- Transient Ischemic Attack
- Hepatocellular Adenoma
- Malignant Paraganglionic Neoplasm
- Schizophrenia
- Dementia
Interacting Proteins
- RHOJ
- TAT
Pathways
- Transport
- Localization
- Regeneration
- Reverse Transcription
- Dna Methylation
- Methylation
- Pathogenesis
- Cell Adhesion
- Cell Proliferation
- Lactation
- Gland Development
- Proteolysis
- Protein Oxidation
PTMs
- Methylation
- Carboxylation
Research Areas
- Neurodegeneration
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLUL
bosterbio.com/bosterbio-gene-info-cards/GLUL
References
PMID: 2888076 by Gibbs C.S., et al. Sequence of a human glutamine synthetase cDNA.
PMID: 1681907 by van den Hoff M.J.B., et al. cDNA sequence of the long mRNA for human glutamine synthase.