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Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: functions by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707).
|glutamine synthetase family|
|Sequence:||1; NC_000001.11 (182378093..182392206, complement)|
Expressed in endothelial cells.
Cytoplasm, cytosol. Microsome. Mitochondrion. Cell membrane; Lipid-anchor. Mainly localizes in the cytosol, with a fraction associated with the cell membrane.