GP1BA Antibodies

Platelet glycoprotein Ib alpha chain (GP1BA)

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. .

Gene Information

Human
Gene Name:	GP1BA
Uniprot:	P07359
Entrez:	2811

Family

Belongs to:
No superfamily

Alternative Names

Antigen CD42b-alpha; BP1BA; BSS; CD42b antigen; CD42b; CD42b-alpha; glycoprotein Ib (platelet), alpha polypeptide; Glycoprotein Ibalpha; GP1B; GP1BA; GPIb alpha; GP-Ib alpha; GPIbA; GPIb-alpha; MGC34595; platelet glycoprotein Ib alpha chain; platelet membrane glycoprotein 1b-alpha subunit

Molecular Weight

Mass (kDA):
71.54 kDA

Genomic Context

Human
Location:	17p13.2
Sequence:	17; NC_000017.11 (4932277..4935023)

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Hemorrhage
• Von Willebrand Disease
• Bleeding Tendency
• 5,10-methylenetetrahydrofolate Reductase Deficiency
• Infarction
• Platelet Type Von Willebrand's Disease
• Coronary Heart Disease
• Heart Diseases
• Von Willebrand Disease, Type 2b
• Myocardial Infarction
• Hypertensive Disease
• Diabetes Mellitus
• Bernard-soulier Syndrome

• Variable Number Tandem Repeat
• Cerebrovascular Accident
• Tissue Adhesions
• Hyperlipidemia
• Dysequilibrium Syndrome
• Von Willebrand Disease, Type 2
• Alloimmunization

Interacting Proteins

• GP1BB
• GP9
• VWF

Pathways

• Platelet Aggregation
• Coagulation
• Hemostasis
• Aging
• Metaphase
• Pathogenesis

• Localization

PTMs

• Phosphorylation

Research Areas

• Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GP1BA

Boster Bio - Best Uses Of The GP1BA Marker

Steven Boster, the High-affinity GP1BA marker and his company are good resources for anyone who is interested in acquiring primary antibodies with high-affinity to be used in diagnostic applications. You can read the articles below to learn about Boster's business, the GP1BA marker and GP1BA antibodies. We also discuss the GP1BA mark, which is a useful tool in the detection of human tumor cells.

Primary antibodies of high affinity

Flow cytometry is a sophisticated laboratory technique that analyzes the presence or absence of specific antibodies using a collection of cells or particles. High-affinity primary antibodies are available from Boster Bio. These antibodies are monoclonal as well as polyclonal. They are highly cited and have been so for over 25 year. Boster has a reagent that can detect specific proteins or complex mixtures of cells.

Boster Bio's rabbit MAbs are made with proprietary PCD technology. These high-affinity clones can be used for both Diagnostics as well as Therapeutics purposes. This process involves proprietary chemical and flow cytometry techniques that prevent B cells releasing antibodies while retaining them on cell surfaces. After separating clones boster bio incubates them for 24 hours with flurochrome conjugated antibody and plasma cells. The most brilliant clones are then taken for downstream screening.

Enzyme-linked immunosorbent assays (ELISAs) work on the same principles as other immunoassay technologies. They use specific antibodies in order to bind the target protein and then relying on a detection system that indicates whether or not the antigen is bound. To maximize the assay's sensitivity, this assay requires high-affinity antibodies. Boster Bio has perfected a technique for coating plates with high affinity primary antibodies. Many scientists trust Boster Bio high affinity antibodies to ensure the best quality.

Polyclonal antibodies are acceptable for research use but can be a stepping-stone to monoclonal antibodies. However, polyclonal antibody cannot be used to amplify the most effective clones. Consequently, they are most commonly used to detect secretive proteins and biomarkers. Luminex(tm), a highly-affinity primary antibodies, is a well-known example.

Dual-labeling allows researchers the ability to ask more questions about a specimen and get richer, more contextual information. Secondary antibodies are often conjugated to other antigens, such as proteins and DNA. Dual-labeling is an option in primary-secondary antibody systems that allows researchers the ability to analyze more specimens while using fewer secondary antigens. This gives researchers more reliable answers and richer information than ever before. Boster Bio high affinity primary antibodies are versatile and an excellent tool for any lab.

WB is the initial validation step. Monoclonal antibodies react more with native proteins than with denatured proteins, so WB results can't be considered absolute evidence. Other validation techniques such Flow cytometry can also be used for confirmation of the specificity monoclonal antibodies. Negative controls are used to identify false-positives in experiments. These techniques are necessary in order to verify the validity and accuracy of the results.

GP1BA marker

The GP1BA genome encodes a protein needed for growth of intestinal cells. Researchers can use this gene to study a variety of diseases. It has been used in numerous studies to identify the gene responsible for intestinal inflammation. Many publications have discussed the best use of this gene. We will discuss some of the most important uses of this gene in this article.