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- Table of Contents
Facts about G-protein coupled receptor 183.
Mediates cell positioning and movement of a number of cells by binding the 7- alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity).
Human | |
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Gene Name: | GPR183 |
Uniprot: | P32249 |
Entrez: | 1880 |
Belongs to: |
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G-protein coupled receptor 1 family |
EBI2; EBI2Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupledreceptor); EBV-induced G-protein coupled receptor 2; Epstein-Barr virus-induced G-protein coupled receptor 2; G protein-coupled receptor 183; GPR183; G-protein coupled receptor 183
Mass (kDA):
41.224 kDA
Human | |
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Location: | 13q32.3 |
Sequence: | 13; NC_000013.11 (99294273..99307399, complement) |
Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes (PubMed:16540462, PubMed:8383238). Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain (PubMed:16540462, PubMed:8383238). Expressed in astrocytes (PubMed:25297897).
Cell membrane; Multi-pass membrane protein.
PMID: 8383238 by Birkenbach M.P., et al. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.
PMID: 16540462 by Rosenkilde M.M., et al. Molecular pharmacological phenotyping of EBI2. An orphan seven- transmembrane receptor with constitutive activity.