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Facts about Glutamate receptor 2.
Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, resulting in the opening of the cation channel, and thereby transforms the chemical signal to an electrical impulse. The receptor then desensitizes quickly and enters a transient dormant state, characterized by the presence of bound agonist.
Human | |
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Gene Name: | GRIA2 |
Uniprot: | P42262 |
Entrez: | 2891 |
Belongs to: |
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glutamate-gated ion channel (TC 1.A.10.1) family |
AMPA 2; AMPA2; GluA2; GluR2; GLURB; GluR-K2; glutamate receptor, ionotropic, AMPA 2; GRIA2; HBGR2
Mass (kDA):
98.821 kDA
Human | |
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Location: | 4q32.1 |
Sequence: | 4; NC_000004.12 (157220584..157370583) |
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity).
If you are looking to use an anti-GluR2 marker to target the GRIA2 gene, you will want to check out Boster Bio. This marker is available for purchase in many forms, including serum, urine, and plasma. Its uses are as diverse as gene therapy and immunotherapy. If you're interested in learning more, check out our Boster Bio review. We have included a list of the best uses for this GRIA2 marker.
The Boster Bio GRIA2 Antibody was recently tested in a variety of applications, including IF, ICC, IHC, and IP. This antibody reacts with Human, Mouse, and Rat GluR2 G protein. In addition to these applications, Boster Bio's GRIA2 Antibody also demonstrates specificity in ELISA and WB assays.
PMID: 8003671 by Sun W., et al. Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain.
PMID: 7523595 by Paschen W., et al. RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.
*More publications can be found for each product on its corresponding product page