Granzyme H Antibodies

AND GZMH ELISA kits, Granzyme H Proteins

Many biological assays use antibodies to detect Granzyme H, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Granzyme H in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Granzyme H antibodies...

We validate the specificity of these antibodies to Granzyme H by testing them on tissues known to express GZMH positively and negatively. Browse below to find the GZMH antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Granzyme H? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the GZMH IHC Guide

GZMH Infographic by Boster Bio

All GZMH Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Granzyme H (G75) GZMH Antibody

Immunohistochemistry (IHC) analyzes of Granzyme H (G75) pAb in paraffin-embedded human breast carcinoma tissue at 1:50

Immunohistochemistry (IHC) analyzes of Granzyme H (G75) pAb in paraffin-embedded human lung carcinoma tissue at 1:50

Human, Mouse, Rat

IF, IHC

$405
Cat # A08559-1
100ul

Granzyme H (GZMH) (NM_033423) Human Over-expression Lysate

Human

$628
Cat # LS002999
20 µg, 100 µg

Human Granzyme H Recombinant Protein

SDS-PAGE

$350
Cat # PROTP20718
Starting from 10ug

GZMH Overview

Facts about Granzyme H.

GZMH 3D structure. Source: alphafold

Granzyme H (GZMH)

Cytotoxic chymotrypsin-like serine protease with preference for aromatic and bulky residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses.

Participates in the antiviral response via direct cleavage of several proteins necessary for viral replication. .

Gene Information

Human
Gene Name:	GZMH
Uniprot:	P20718
Entrez:	2999

Family

Belongs to:

peptidase S1 family

Alternative Names

Cathepsin G-like 2; CCP-X; CCP-Xcytotoxic T-lymphocyte-associated serine esterase 1; CGL2; CGL-2; CSP-Ccytotoxin serine protease-C; CTLA1; CTSGL2; CTSGL2granzyme H; Cytotoxic serine protease C; Cytotoxic T-lymphocyte proteinase; EC 3.4.21; EC 3.4.21.-; EC 3.4.21.79; granzyme H (cathepsin G-like 2, protein h-CCPX); Granzyme H; GrzH; GZMH

Molecular Weight

Mass (kDA):
27.315 kDA

Genomic Context


Human

Location:	14q12
Sequence:	14; NC_000014.9 (24606480..24609763, complement)

Tissue Specificity

Constitutively expressed in NK cells.

Subcellular Localizations

Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes.

Diseases

Neoplasms
Hepatitis
Liver Carcinoma
Malignant Neoplasm Of Breast
Malignant Paraganglionic Neoplasm
Hepatitis B
Hepatitis C
Mitochondrial Damage
Inflammatory Response
Carcinoma
Peripheral Vascular Diseases
Adenovirus Infections

Malignant Neoplasms
Innate Immune Response
Lymphoma
Mammary Neoplasms
Inflammation
Vascular Diseases
Lymphoid Leukemia

Pathways

Cell Death
Cytolysis
Immune Response
Cell Activation
Programmed Cell Death
T Cell Activation
Cytokine Secretion
Menopause
Mitochondrial Depolarization
Localization

Inflammatory Response
Dna Replication
Menarche
Exocytosis
Secretion

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GZMH

References

PMID: 2193684 by Meier M., et al. Cloning of a gene that encodes a new member of the human cytotoxic cell protease family.

PMID: 2049336 by Haddad P., et al. Structure and evolutionary origin of the human granzyme H gene.