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Granzyme H Antibodies
AND GZMH ELISA kits, Granzyme H Proteins
Many biological assays use antibodies to detect Granzyme H, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Granzyme H in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Granzyme H antibodies...
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GZMH Overview
Facts about Granzyme H.
Granzyme H (GZMH)
Cytotoxic chymotrypsin-like serine protease with preference for aromatic and bulky residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses.
Participates in the antiviral response via direct cleavage of several proteins necessary for viral replication. .
Gene Information
| Human | |
|---|---|
| Gene Name: | GZMH |
| Uniprot: | P20718 |
| Entrez: | 2999 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
Cathepsin G-like 2; CCP-X; CCP-Xcytotoxic T-lymphocyte-associated serine esterase 1; CGL2; CGL-2; CSP-Ccytotoxin serine protease-C; CTLA1; CTSGL2; CTSGL2granzyme H; Cytotoxic serine protease C; Cytotoxic T-lymphocyte proteinase; EC 3.4.21; EC 3.4.21.-; EC 3.4.21.79; granzyme H (cathepsin G-like 2, protein h-CCPX); Granzyme H; GrzH; GZMH
Molecular Weight
Mass (kDA):
27.315 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q12 |
| Sequence: | 14; NC_000014.9 (24606480..24609763, complement) |
Tissue Specificity
Constitutively expressed in NK cells.
Subcellular Localizations
Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes.
Diseases
- Neoplasms
- Hepatitis
- Liver Carcinoma
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Hepatitis B
- Hepatitis C
- Mitochondrial Damage
- Inflammatory Response
- Carcinoma
- Peripheral Vascular Diseases
- Adenovirus Infections
Pathways
- Cell Death
- Cytolysis
- Immune Response
- Cell Activation
- Programmed Cell Death
- T Cell Activation
- Cytokine Secretion
- Menopause
- Mitochondrial Depolarization
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GZMH
bosterbio.com/bosterbio-gene-info-cards/GZMH
References
PMID: 2193684 by Meier M., et al. Cloning of a gene that encodes a new member of the human cytotoxic cell protease family.
PMID: 2049336 by Haddad P., et al. Structure and evolutionary origin of the human granzyme H gene.