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GUCY2D Antibodies
AND GUCY2D ELISA kits, GUCY2D Proteins
Many biological assays use antibodies to detect GUCY2D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GUCY2D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GUCY2D antibodies...
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GUCY2D Overview
Facts about Retinal guanylyl cyclase 1.
Retinal guanylyl cyclase 1 (GUCY2D)
Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.
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Gene Information
| Human | |
|---|---|
| Gene Name: | GUCY2D |
| Uniprot: | Q02846 |
| Entrez: | 3000 |
Family
| Belongs to: |
|---|
| adenylyl cyclase class-4/guanylyl cyclase family |
Alternative Names
CORD6cone rod dystrophy 5/6; CYGD; EC 4.6.1; guanylate cyclase 2D, membrane (retina-specific); Guanylate cyclase 2D, retinal; GUC1A4; GUC2DCORD5; LCA; LCA1RCD2; retGC; RETGC1; RETGC-1EC 4.6.1.2; retinal guanylyl cyclase 1; Rod outer segment membrane guanylate cyclase; ROSGC; ROS-GC; ROS-GC1
Molecular Weight
Mass (kDA):
120.059 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (8002615..8020342) |
Tissue Specificity
Retina. Localized exclusively in the nuclei and inner segments of the rod and cone photoreceptor cells.
Subcellular Localizations
Photoreceptor outer segment membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Diseases
- Amaurosis
- Leber Congenital Amaurosis
- Dystrophy
- Blind Vision
- Retinitis Pigmentosa
- Retinal Degeneration
- Retinal Dystrophies
- Retinal Diseases
- Visual Impairment
- Optic Atrophy, Hereditary, Leber
- Atrophy
- Optic Atrophies, Hereditary
Interacting Proteins
- RD3
Pathways
- Phototransduction
- Transport
- Visual Behavior
- Localization
- Synaptic Transmission
- Associative Learning
- Nuclear Transport
- Translation
- Phagocytosis
- Cell Death
- Water Homeostasis
PTMs
- Disulfide bond
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GUCY2D
bosterbio.com/bosterbio-gene-info-cards/GUCY2D
References
PMID: 1356371 by Shyjan A.W., et al. Molecular cloning of a retina-specific membrane guanylyl cyclase.
PMID: 7806240 by Oliveira L., et al. Human retinal guanylate cyclase (GUC2D) maps to chromosome 17p13.1.