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- Table of Contents
HBEGF Antibodies
AND HBEGF ELISA kits, HBEGF Proteins
Many biological assays use antibodies to detect HBEGF, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HBEGF in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HBEGF antibodies...
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HBEGF Infographic by Boster Bio
All HBEGF Products
Product
Figures
Specificity
Applications
Price
Human HBEGF ELISA Kit PicoKine®
5 Citations 10 Q&As
Human
ELISA
$499
Cat # EK0770
96 wells/kit, with removable strips.
Cat # EK0770
96 wells/kit, with removable strips.
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$370
Cat # A01759-3
100 μg/vial
Cat # A01759-3
100 μg/vial
Cynomolgus monkey, Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01759-2
100 μg
Cat # M01759-2
100 μg
Cynomolgus monkey, Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01759-3
100 μg
Cat # M01759-3
100 μg
HBEGF Overview
Facts about Proheparin-binding EGF-like growth factor.
Proheparin-binding EGF-like growth factor (HBEGF)
Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation.
May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | HBEGF |
| Uniprot: | Q99075 |
| Entrez: | 1839 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
diphtheria toxin receptor (heparin-binding epidermal growth factor-like growthfactor); Dtr; DTRHEGFLdiphtheria toxin receptor (heparin-binding EGF-like growth factor); Dts; DTSF; HBEGF; HB-EGF; Hegfl; heparin-binding EGF-like growth factor; heparin-binding epidermal growth factor; proheparin-binding EGF-like growth factor
Molecular Weight
Mass (kDA):
23.067 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.3 |
| Sequence: | 5; NC_000005.10 (140332843..140346603, complement) |
Subcellular Localizations
[Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Inflammation
- Neoplasms
- Pre-eclampsia
- Diphtheria
- Malignant Neoplasm Of Breast
- Hypoxia
- Hypertrophy
- Tissue Adhesions
- Mammary Neoplasms
- Reperfusion Injury
- Anoxia
- Cell Invasion
Pathways
- Cell Proliferation
- Secretion
- Cell Migration
- Immune Response
- Cell Cycle
- Wound Healing
- Localization
- Cell Death
- Pathogenesis
- Cell Adhesion
- Secondary Growth
- Fertilization
- Coagulation
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HBEGF
bosterbio.com/bosterbio-gene-info-cards/HBEGF
References
PMID: 1840698 by Higashiyama S., et al. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.
PMID: 1556128 by Higashiyama S., et al. Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.
2 Publications of Boster HBEGF Antibodies & ELISA Kits
- PubMed ID: 10.1124/mol.116.107854, GABABR-Induced EGFR Transactivation Promotes Migration of Human Prostate Cancer ...
- PubMed ID: 10.1007/s12013-014-0026-1, The Adhesion AND Growth of Both the Human Primary Gingival Epithelial Cells and ...
*More publications can be found for each product on its corresponding product page