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- Table of Contents
1 Citations 5 Q&As
Facts about Huntingtin-interacting protein 1.
Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218).
| Human | |
|---|---|
| Gene Name: | HIP1 |
| Uniprot: | O00291 |
| Entrez: | 3092 |

| Belongs to: |
|---|
| SLA2 family |

HIP-1; HIP-I; huntingtin interacting protein 1; huntingtin-interacting protein 1; Huntingtin-interacting protein I; ILWEQ; MGC126506
Mass (kDA):
116.221 kDA

| Human | |
|---|---|
| Location: | 7q11.23 |
| Sequence: | 7; NC_000007.14 (75533298..75738976, complement) |
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.






PMID: 11788820 by Gervais F.G., et al. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
PMID: 9140394 by Kalchman M.A., et al. HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.