HLA-DMB Antibodies

AND HLA-DMB ELISA kits, HLA-DMB Proteins

Many biological assays use antibodies to detect HLA-DMB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HLA-DMB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HLA-DMB antibodies...

We validate the specificity of these antibodies to HLA-DMB by testing them on tissues known to express HLA-DMB positively and negatively. Browse below to find the HLA-DMB antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HLA-DMB Infographic by Boster Bio

All HLA-DMB Products

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Product

Figures

Specificity

Applications

Price

Anti-HLA DMB/HLA-DMB Antibody Picoband®

2 Citations 4 Q&As

Anti-HLA DMB antibody, PA1788, Western blottingAll lanes: Anti HLA DMB (PA1788) at 0

miR-411-5p activate p38MAPK pathway by targeting SPRY4-induced terminal differentiation of RMS

Human

IHC, WB

$370
Cat # PA1788
100 μg/vial

Anti-HLA DMB Rabbit Monoclonal Antibody

Western blot analysis of HLA DMB expression in Raji cell lysate

Human

Flow Cytometry, WB

$370
Cat # M03526
100 μl/vial

HLA DMB (HLA-DMB) (NM_002118) Human Over-expression Lysate

Human

$628
Cat # LS003109
20 µg, 100 µg

HLA-DMB Overview

Facts about HLA class II histocompatibility antigen, DM beta chain.

HLA-DMB 3D structure. Source: alphafold

HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.

Gene Information

Human
Gene Name:	HLA-DMB
Uniprot:	P28068
Entrez:	3109

Family

Belongs to:

MHC class II family

Alternative Names

class II histocompatibility antigen, M beta chain; D6S221E; DMB; major histocompatibility complex, class II, DM beta; MHC class II antigen DMB; MHC class II antigen HLA-DM beta chain; MHC class II HLA-DMB; Really interesting new gene 7 protein; RING7HLA class II histocompatibility antigen, DM beta chain

Molecular Weight

Mass (kDA):
28.943 kDA

Genomic Context


Human

Location:	6p21.32
Sequence:	6; NC_000006.12 (32934636..32941028, complement)

Subcellular Localizations

Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Localizes to late endocytic compartment. Associates with lysosome membranes.

Diseases

Dysequilibrium Syndrome
Autoimmune Reaction
Malignant Neoplasms
Neoplasms
Rheumatoid Arthritis
Autoimmune Diseases
Sclerosis
Dermatitis
Multiple Sclerosis
Diabetes Mellitus
Arthritis
Spondylitis

Burkitt Lymphoma
Behcet Syndrome
Thyroid Diseases
Carcinoma
Immunologic Deficiency Syndromes
Rheumatism
Severe Combined Immunodeficiency

Interacting Proteins

HLA-DMA

Pathways

Transport
Methylation
Intracellular Transport
Antigen Processing And Presentation
Histone Acetylation
Chromatin Modification
Pathogenesis

Localization

PTMs

Acetylation

Methylation

Research Areas

Asthma
Diabetes Research
Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HLA-DMB

References

PMID: 1922365 by Kelly A.P., et al. A new human HLA class II-related locus, DM.

PMID: 8034636 by Radley E., et al. Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex.