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- Table of Contents
Facts about HLA class II histocompatibility antigen, DM beta chain.
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Human | |
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Gene Name: | HLA-DMB |
Uniprot: | P28068 |
Entrez: | 3109 |
Belongs to: |
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MHC class II family |
class II histocompatibility antigen, M beta chain; D6S221E; DMB; major histocompatibility complex, class II, DM beta; MHC class II antigen DMB; MHC class II antigen HLA-DM beta chain; MHC class II HLA-DMB; Really interesting new gene 7 protein; RING7HLA class II histocompatibility antigen, DM beta chain
Mass (kDA):
28.943 kDA
Human | |
---|---|
Location: | 6p21.32 |
Sequence: | 6; NC_000006.12 (32934636..32941028, complement) |
Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Localizes to late endocytic compartment. Associates with lysosome membranes.
Do you need an overview of HLA/DMB/DMA and DMA? Then read on! This article will demonstrate how these Antigens in BosterBio are processed and presented. Once you have read this article, you will be able to use Boster Bio HLA-DMA or DMB markers. Before you can use these markers, it is important to understand how they work.
The HLA/DMB genes are a key immunogen in the diagnosis and research of many disorders including cancer and inflammatory intestinal disease. The HLA-DMB gene is highly conserved among human populations, and has been identified in the majority of people. The marker's polymorphism can be explained by genetic and immune factors. A recent study involved 113 DMD patients as a group of study participants to determine the marker's polymorphism.
DMB is expressed on thyroid thyrocytes, but it does not spontaneously transform in vitro. This is one of the reasons DMB expression in thyroid is so common in Thyroid-stimulating Hormone-treated patients. This gene is highly expressed in differentiated tissues, making it an excellent choice for studies on the transcriptional regulation HLA/DMB gene genes.
The HLA–DMB gene regulates antigen-presentation on MHC class I molecules. It is expressed at basal conditions and then becomes more active after 6 hours of IFN-g treatment. It remained the same for 48 hours. The PCR product of the DMB gene appeared in a single band containing 300 to 400 base pair. Its expected size will be 32 kD.
The HLA-DR3 gene forms part of the human class 2 major histocompatibility system. The HLA DR3 tetramer includes an immunodominant HLA DR3-restricted, T-cell epitope. It is derived mainly from Mycobacterium tuberculosis' 65-kDa Heat-Shock protein and the Cytomegalovirus pp65 lower Matrix protein.
The HLA-DMB marker is a polymorphic protein with a heterodimer structure containing two parts: the alpha chain and the beta chain. It is expressed on the surfaces of antigen-presenting cell and plays a central part in the immune response. Boster Bio offers a variety of products for the detection of HLA-DMB. These are some of the best uses of this marker.
The HLA-DMB gene encodes the histocompatibility antigen (HLA-DMB). It plays a crucial role in the process of cross-presentation of antigenic peptides by regulating the interaction of the class II molecules, HLA-DO and HLA-DM. The HLA/DMB marker undergoes rigorous quality control and has been validated in multiple application. The company also provides solid technical support to support the use of its HLA-DMB reagents.
Although HLA-DMB is not an immune cell antigen, it is important for a number of immunological processes. Partially degrading is how antigens present by CD4+T cells are processed. The antigenic propeptides must adhere to MHC class I molecules and reach the cell surface in order to be recognized by the immune systems.
Antibodies that are specific against this antigen may be useful tools for analyzing T cell responses to antigens. These antibodies may be used to investigate the HLA/DMB-complement's function and how T cell recognize antigens. It is also useful in research on the function and recognition of T-cells. It has been shown to enhance T-cell recognition of peptides.
The HLA/DMB gene encodes proteins which play a crucial role in the adaptive immunity response in vertebrates. These antigens can interact with oligopeptides and contribute to an adaptive immune system. Positive selection across species results in high polymorphisms of MHC genes as well as the sharing and overlapping of allelic linesages. It remains to be determined how this selective process works. However, the current study suggests there are a number of strategies that can be used to detect HLA–DMB.
The expression of DMB in thyrocytes has been reported. It is unknown whether the genes DMB are necessary for antigen processing in the thyroid gland. Thyrocytes can present antigens to T cell receptors but are considered nonprofessional APCs. This could have been an early case of AITD. Autoimmunity has been associated to the HLA/DMB marker.
A powerful antibody can help your research, and Boster Bio has the tools and expertise to make this happen. Their antibodies are validated on multiple platforms using both known positive and negative samples, and are highly specific and have high affinity for their targets. There are many options for visualizing antibody-antigen binding. There are also several enzymes that can produce color. Antibody/antigen binding is a useful tool for studying the distribution and location cells components. In addition to this, Boster rewards the first reviewers of each of their products with product credits, thereby rewarding scientists globally.
Antigen-presenting cell, or APCs, are how the immune system recognizes pathogens. These cells consume and digest pathogens, and inform the adaptive immune response about the presence of infection. Once the APCs have digested a pathogen, antigen fragments are released to the surface. These antigen fragments serve as indicators for immune cells. Plasma cells are the B and T cells that activate the adaptive immune response. They require the input of APCs.
The MHC-II LECs performs two functions. It directs adaptive immune system through antigen presentations and regulates immunity by PD-L1 Signaling. Barrier immunity is dependent on antigen presentation. LECs must interact and communicate with CD4+ T cells in order to make it work. The MHC II on LECs controls immune response, so the MHC II on LECs is critical for regulation of barrier immunity.
PMID: 1922365 by Kelly A.P., et al. A new human HLA class II-related locus, DM.
PMID: 8034636 by Radley E., et al. Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex.