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- Table of Contents
Facts about Heterogeneous nuclear ribonucleoproteins A2/B1.
Packaging plays a role in a variety of processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Types hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA from the nucleus.
Human | |
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Gene Name: | HNRNPA2B1 |
Uniprot: | P22626 |
Entrez: | 3181 |
Belongs to: |
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No superfamily |
DKFZp779B0244; FLJ22720; heterogeneous nuclear ribonucleoprotein A2/B1; heterogeneous nuclear ribonucleoprotein B1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1hnRNP A2/B1; HNRPB1; nuclear ribonucleoprotein particle A2 protein; RNPA2; SNRPB1
Mass (kDA):
37.43 kDA
Human | |
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Location: | 7p15.2 |
Sequence: | 7; NC_000007.14 (26189920..26200775, complement) |
Nucleus. Nucleus, nucleoplasm. Cytoplasm. Cytoplasmic granule. Secreted, extracellular exosome. Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Component of ribonucleosomes (PubMed:17289661). Not found in the nucleolus (PubMed:17289661). Found in exosomes following sumoylation (PubMed:24356509).; [Isoform A2]: Nucleus. Cytoplasm. Predominantly nucleoplasmic, however is also found in the cytoplasm of cells in some tissues (PubMed:17289661).
You've come to the right place if are looking for a high-affinity primary antibodies. Boster offers a array of highly-specific antigens as well as products that are specifically designed for different species. Learn more about this marker and how Boster can assist you. Boster is available to scientists from all over the world and comes with a myriad of applications.
Flow cytometry is a method to study particles and cells. It is a versatile tool. Boster Bio provides high-affinity primary antibodies to meet this need. Their antibodies are both monoclonal and polyclonal, and have been consistently cited for their high-affinity properties. Boster is a trusted source of high-specific antibodies as are ELISA kits that allow scientists to test the levels of antigens in their samples, which improve the diagnostic and research methods.
The company also offers quality kits and Reagents that can be used for ELISA and WB. The range of products from Boster includes rabbit polyclonal antibody products that can be used in conjunction with human and mouse samples. The Boster Quality Guarantee assures you that the primary antibody you purchase will perform in the manner it's advertised. Boster Bio also offers a free secondary antibody when you purchase an antibody that is the primary one. All Boster Bio antibodies have been rigorously tested and validated, and are suitable for use in ELISA, WB, FC, IHC, and ELISA.
The sequences of antibodies are shown in Supplementary Figs. 2 3, 4. 2 and 3. To verify their purity under nondenaturing conditions, the antibodies were also subjected to an analytical analysis using size-exclusion analysis chromatography. All antibodies tested had greater than 95% monomer content. This is a significant benefit when analyzing antibody purification.
The antibody is distinguished by its high affinity and low immunogenicity. Its high affinity and low dissociation rates may be beneficial in the treatment of hypercholesterolemia as well as other cardiovascular diseases. While it has not yet been tested clinically but it is believed to have some therapeutic benefit. These antibodies can be useful in research, diagnosis, and treatment. Boster Bio has the ability to target multiple targets at once and is well-positioned to offer high-affinity primary antibodies to medical professionals.
To further examine the IC50 values of isolated antibodies against the RBD of SARS-CoV-2, the isolates were immobilized on microbeads. These RBD-coated beads were then incubated with VHH-72 or 13I1 nanobodies. The beads were then washed twice with ice-cold PBSB. The beads were then analyzed by flow cytometry.
mAb 5D5 recognizes PfCSP as a potential functional location on the surface Pf sporozoites. This indicates that the affinity-antigen properties of PfCSP are superior. In in vitro affinity maturation mimics natural affinity maturation but is the same as in vivo. The result is a highly specific antibody that is able to bind the target antigen with high affinity.
Scientists begin by immunizing animals using antigens, and then extract antibodies from their sera or eggs. These recombinant antibody are free from cell-line drift which is crucial to achieve the highest antigen specificity. This method is extremely reproducible in research. Because it involves animal immunization it is extremely unlikely of contamination.
Secondary antibodies such as rabbit IgG or mouse IgG can be used to label specimens in a double fashion. It allows researchers to ask more questions about each specimen, and provide more precise answers and context data. Utilizing a primary antibody scientists can simultaneously determine the amount of an antigen and make sure it binds to the corresponding antigen. With a secondary antibody they can also perform ELISA to study the activity of certain cells.
Single B cell screening allows scientists to make high-affinity antibodies against a target antigen within a week after isolation. This method involves regaining VH/VL antibody genes that are paired from immunized animals and patients in convalescence. Scientists then test the potential antibodies. A biotherapeutic can be made from a high-affinity antibody. The process is fast and inexpensive.
Single-domain antibodies that are found in camelids resemble to monoclonal antibodies. However, the light chain is absent and the antigen-binding site sits within the heavy-chain variable domain. While this protein is relatively simple to produce and is thermostable, its application in the detection of small molecules has only been reported a handful of times. VHHs are the best choice to detect small molecules. Although their affinity for small molecules is not great but they are highly specific and is useful in many research applications.
PMID: 2557628 by Burd C.G., et al. Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.
PMID: 8029005 by Biamonti G., et al. Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1.