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- Table of Contents
HSPG2 Antibodies
AND HSPG2 ELISA kits, HSPG2 Proteins
Many biological assays use antibodies to detect HSPG2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HSPG2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HSPG2 antibodies...
Designing a Western blot for HSPG2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HSPG2 Western Blot GuideDesigning an IHC experiment for HSPG2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the HSPG2 IHC GuideHSPG2 Infographic by Boster Bio
All HSPG2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK1760
96 wells/kit, with removable strips.
Cat # EK1760
96 wells/kit, with removable strips.
Human
IHC, WB
$370
Cat # PB9277
100 μg/vial
Cat # PB9277
100 μg/vial
Human
ELISA
$500
Cat # EZ1760
5 plates/kit
Cat # EZ1760
5 plates/kit
HSPG2 Overview
Facts about Basement membrane-specific heparan sulfate proteoglycan core protein.
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2)
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective.
It functions as an attachment substrate for cells. Plays essential roles in vascularization.
Gene Information
| Human | |
|---|---|
| Gene Name: | HSPG2 |
| Uniprot: | P98160 |
| Entrez: | 3339 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
basement membrane-specific heparan sulfate proteoglycan core protein; endorepellin (domain V region); Endorepellin; heparan sulfate proteoglycan 2; HSPG; HSPG2; perlecan proteoglycan; Perlecan; PLCSchwartz-Jampel syndrome 1 (chondrodystrophic myotonia); PRCAN; SJA; SJS; SJS1
Molecular Weight
Mass (kDA):
468.83 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.12 |
| Sequence: | 1; NC_000001.11 (21822244..21937310, complement) |
Tissue Specificity
Found in the basement membranes.
Subcellular Localizations
Secreted, extracellular space, extracellular matrix, basement membrane.
Diseases
- Osteochondrodysplasias
- Dysplasia
- Neoplasms
- Schwartz-jampel Syndrome
- Malignant Neoplasms
- Hypertrophy
- Tissue Adhesions
- Lingual-facial-buccal Dyskinesia
- Alzheimer's Disease
- Dyskinetic Syndrome
- Schizophrenia
- Diabetic Nephropathy
Interacting Proteins
- KDR
Pathways
- Cell Growth
- Cell Adhesion
- Localization
- Ossification
- Cartilage Development
- Cell Proliferation
- Pathogenesis
- Secretion
- Transport
- Endochondral Ossification
- Angiogenesis
- Cell Activation
- Muscle Cell Proliferation
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSPG2
bosterbio.com/bosterbio-gene-info-cards/HSPG2
References
PMID: 1730768 by Kallunki P., et al. Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
PMID: 8234307 by Cohen I.R., et al. Structural characterization of the complete human perlecan gene and its promoter.
3 Publications of Boster HSPG2 Antibodies & ELISA Kits
- PubMed ID: PMID:27830002, Comparative analysis of the interaction of HSPs in dendritic cells, macrophages,...
- PubMed ID: 10.1007/s11011-020-00551-0, Curcumin attenuates cytoplasmic/endoplasmic reticulum stress, apoptosis and chol...
- PubMed ID: , Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture
*More publications can be found for each product on its corresponding product page