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- Table of Contents
Facts about 5-hydroxytryptamine receptor 1A.
Ligand binding causes a conformation change that triggers signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling through G proteins and mediate activation of alternative signaling pathways.
Human | |
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Gene Name: | HTR1A |
Uniprot: | P08908 |
Entrez: | 3350 |
Belongs to: |
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G-protein coupled receptor 1 family |
5-HT1a receptor; 5HT1A; 5-HT1A; 5-HT-1A; 5-HT1A5-hydroxytryptamine receptor 1A; 5-hydroxytryptamine (serotonin) receptor 1A; ADRB2RL1; ADRB2RL15HT1a; ADRBRL1; G protein coupled receptor; G-21; guanine nucleotide-binding regulatory protein-coupled receptor; HTR1A; PFMCD; Serotonin receptor 1A
Mass (kDA):
46.107 kDA
Human | |
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Location: | 5q12.3 |
Sequence: | 5; NC_000005.10 (63957874..63962445, complement) |
Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.
Cell membrane; Multi-pass membrane protein.
Boster Bio's primary antibodies are an excellent source of primary antibodies that are able to detect HTR1A within the body. These antibodies are high-affinity, and have been validated by Western Blotting, Immunohistochemistry, and ELISA methods. They have a track of quality control and reproducibility.
Steven Boster's primary antibodies , as well as the HTR1A marker are the most reliable sources to find an antibody against the 5-HT1A receptor. Boster's antibody has been validated across a variety platforms with positive and negative samples. Boster's antibodies are specific and have high affinity. Boster offers product credits to the first reviewers. The Boster company also offers incentives to all scientists worldwide.
PMID: 3041227 by Kobilka B.K., et al. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins.
PMID: 15014171 by Kitano T., et al. Human-specific amino acid changes found in 103 protein-coding genes.