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- Table of Contents
HTR1A Antibodies
AND HTR1A ELISA kits, HTR1A Proteins
Many biological assays use antibodies to detect HTR1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HTR1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HTR1A antibodies...
Designing a Western blot for HTR1A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HTR1A Western Blot GuideHTR1A Infographic by Boster Bio
All HTR1A Products
Product
Figures
Specificity
Applications
Price
Anti-5HT1A Receptor/HTR1A Antibody Picoband®
5 Citations
Human, Rat
IHC, WB
$370
Cat # PA1647
100 μg/vial
Cat # PA1647
100 μg/vial
HTR1A Overview
Facts about 5-hydroxytryptamine receptor 1A.
5-hydroxytryptamine receptor 1A (HTR1A)
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances.
Ligand binding causes a conformation change that triggers signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling through G proteins and mediate activation of alternative signaling pathways.
Gene Information
| Human | |
|---|---|
| Gene Name: | HTR1A |
| Uniprot: | P08908 |
| Entrez: | 3350 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
5-HT1a receptor; 5HT1A; 5-HT1A; 5-HT-1A; 5-HT1A5-hydroxytryptamine receptor 1A; 5-hydroxytryptamine (serotonin) receptor 1A; ADRB2RL1; ADRB2RL15HT1a; ADRBRL1; G protein coupled receptor; G-21; guanine nucleotide-binding regulatory protein-coupled receptor; HTR1A; PFMCD; Serotonin receptor 1A
Molecular Weight
Mass (kDA):
46.107 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q12.3 |
| Sequence: | 5; NC_000005.10 (63957874..63962445, complement) |
Tissue Specificity
Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Depressive Disorder
- Major Depressive Disorder
- Anxiety Disorders
- Mental Disorders
- Cancer Patients And Suicide And Depression
- Stress, Psychological
- Dysequilibrium Syndrome
- Schizophrenia
- Mood Disorders
- Nervousness
- Cholangiocarcinoma
Interacting Proteins
- FGFR1
- GALR1
- GPR39
- HTR2A
Pathways
- Pathogenesis
- Transport
- Response To Fluoxetine
- Response To Antidepressant
- Response To Stress
- Brain Development
- Neurogenesis
- Oxidative Phosphorylation
- Reflex
- Swimming
- Thigmotaxis
- Response To Clozapine
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
- GPCR
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HTR1A
bosterbio.com/bosterbio-gene-info-cards/HTR1A
References
PMID: 3041227 by Kobilka B.K., et al. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins.
PMID: 15014171 by Kitano T., et al. Human-specific amino acid changes found in 103 protein-coding genes.