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- Table of Contents
HTR2B Antibodies
AND HTR2B ELISA kits, HTR2B Proteins
Many biological assays use antibodies to detect HTR2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HTR2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HTR2B antibodies...
Designing a Western blot for HTR2B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HTR2B Western Blot GuideHTR2B Infographic by Boster Bio
All HTR2B Products
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HTR2B Overview
Facts about 5-hydroxytryptamine receptor 2B.
5-hydroxytryptamine receptor 2B (HTR2B)
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538).
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538).
Gene Information
| Human | |
|---|---|
| Gene Name: | HTR2B |
| Uniprot: | P41595 |
| Entrez: | 3357 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
5-HT(2B); 5HT2B; 5-HT2B; 5-HT-2B; 5-HT2B5-HT 2B receptor; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; HTR2B; Serotonin receptor 2B
Molecular Weight
Mass (kDA):
54.298 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.1 |
| Sequence: | 2; NC_000002.12 (231108230..231126172, complement) |
Tissue Specificity
Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
Diseases
- Diabetes Mellitus
- Obesity
- Carcinoma
- Neoplasms
- Gestational Diabetes
- Impaired Glucose Tolerance
- Intrahepatic Cholangiocarcinoma
- Pregnancy Complications
- Substance-related Disorders
- Tumors Of Adrenal Cortex
- Migraine With Aura
- Behavioral Tic
Interacting Proteins
- HTR2A
- HTR2C
Pathways
- Transport
- Cell Proliferation
- Lactation
- Parturition
- Brain Development
- Eating Behavior
- Gluconeogenesis
- Energy Homeostasis
- Regeneration
- Reverse Transcription
PTMs
Research Areas
- GPCR
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HTR2B
bosterbio.com/bosterbio-gene-info-cards/HTR2B
References
PMID: 8143856 by Schmuck K., et al. Cloning and functional characterization of the human 5-HT2B serotonin receptor.
PMID: 7926008 by Choi D.S., et al. The human serotonin 5-HT2B receptor: pharmacological link between 5- HT2 and 5-HT1D receptors.