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- Table of Contents
Facts about 5-hydroxytryptamine receptor 2B.
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538).
| Human | |
|---|---|
| Gene Name: | HTR2B |
| Uniprot: | P41595 |
| Entrez: | 3357 |

| Belongs to: |
|---|
| G-protein coupled receptor 1 family |

5-HT(2B); 5HT2B; 5-HT2B; 5-HT-2B; 5-HT2B5-HT 2B receptor; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; HTR2B; Serotonin receptor 2B
Mass (kDA):
54.298 kDA

| Human | |
|---|---|
| Location: | 2q37.1 |
| Sequence: | 2; NC_000002.12 (231108230..231126172, complement) |
Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.






PMID: 8143856 by Schmuck K., et al. Cloning and functional characterization of the human 5-HT2B serotonin receptor.
PMID: 7926008 by Choi D.S., et al. The human serotonin 5-HT2B receptor: pharmacological link between 5- HT2 and 5-HT1D receptors.