HTR3A Antibodies

AND HTR3A ELISA kits, HTR3A Proteins

Many biological assays use antibodies to detect HTR3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HTR3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HTR3A antibodies...

We validate the specificity of these antibodies to HTR3A by testing them on tissues known to express HTR3A positively and negatively. Browse below to find the HTR3A antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HTR3A Infographic by Boster Bio

All HTR3A Products

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Anti-SR-3A HTR3A Antibody

Western blot analysis of lysates from HT-29 cells, using 5-HT-3A Antibody

Western blot analysis of the lysates from HepG2 cells using 5-HT-2B antibody

Human

ELISA, IF, IHC, WB

$415
Cat # A02391-1
100ul

5HT3A receptor (HTR3A) (NM_213621) Human Over-expression Lysate

5HT3A receptor (HTR3A) Human Over-expression Lysates NM_000869

Human

$960
Cat # LS003359
20 µg, 100 µg

HTR3A Overview

Facts about 5-hydroxytryptamine receptor 3A.

HTR3A 3D structure. Source: alphafold

5-hydroxytryptamine receptor 3A (HTR3A)

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons.

It is a cation-specific, but otherwise relatively nonselective, ion channel. .

Gene Information

Human
Gene Name:	HTR3A
Uniprot:	P46098
Entrez:	3359

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

5-HT-3,5-HT3-A; 5HT3A; 5-HT3A; 5-HT3R5-hydroxytryptamine receptor 3A; 5-hydroxytryptamine (serotonin) receptor 3A; 5-hydroxytryptamine receptor 3,5-HT3A5HT3R; HTR35HT3 serotonin receptor; HTR3A; Serotonin receptor 3A; Serotonin-gated ion channel receptor

Molecular Weight

Mass (kDA):
55.28 kDA

Genomic Context


Human

Location:	11q23.2
Sequence:	11; NC_000011.10 (113975075..113990313)

Tissue Specificity

Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Diseases

Schizophrenia
Nervousness
Depressive Disorder
Nausea
Vomiting
Pain
Irritable Bowel Syndrome
Anxiety Disorders
Mental Disorders
Mood Disorders
Nausea And Vomiting
Malignant Neoplasms

Bipolar Disorder
Cholangiocarcinoma
Neoplasms
Stress, Psychological
Major Depressive Disorder
Dyspepsia
Postoperative Nausea And Vomiting

Interacting Proteins

HTR3C
HTR3D

Pathways

Cognition
Pathogenesis
Transport
Synaptic Transmission
Response To Clozapine
Cell Differentiation
Bioluminescence
Response To Stress
Mature B Cell Differentiation
Peristalsis
Dna Methylation
Neurogenesis
Neuron Differentiation

Abscission
Localization
Cytokinesis
Methylation
Response To Risperidone
Noradrenergic Neuron Differentiation
Neural Crest Formation

PTMs

Phosphorylation

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HTR3A

References

PMID: 7565620 by Miyake A., et al. Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.

PMID: 8848005 by Belelli D., et al. Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.