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- Table of Contents
5 Citations 6 Q&As
2 Citations 1 Q&As
Facts about Heparanase.
It's basically inactive at neutral pH but becomes active under acidic conditions like during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation.
Human | |
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Gene Name: | HPSE |
Uniprot: | Q9Y251 |
Entrez: | 10855 |
Belongs to: |
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glycosyl hydrolase 79 family |
EC 3.2; Endo-glucoronidase; HEP; Heparanase; Heparanase-1; HPA1; HPAheparanase exon 9 and 10 deletion; HPR1; HPSE; HPSE1heparanase-1; HSE1; HSE1heparanase exon10-deletion
Mass (kDA):
61.149 kDA
Human | |
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Location: | 4q21.23 |
Sequence: | 4; NC_000004.12 (83292461..83335153, complement) |
Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henle's and Huxley's layers of inner the root sheath (IRS) at anagen phase.
Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity).
The HPSE marker is a well-known DNA damage detection tool. It is a caspase family of cysteine proteases that respond in a sequence to stimulations for apoptosis. Pro-apoptotic stimuli can include cytotoxic T-cell lymphoma-associated proteins (CTA) as well as tumor neoplasm factor, growth factor receptor bound protein (FasL), Granzyme B and calcium channels. Boster Bio offers a variety of reagents and solutions to DNA analysis.
With more than 25 years of experience, Boster Bio has developed high-quality antibodies as well as ELISA kits for use in research. Boster Bio's commitment is to quality and consistency, and ensuring that every product works exactly according to the specifications. Their dedication to customer service and quality is evident in the many publications they have received. Their products are utilized all over the world by scientists. Boster Bio is the best choice for top-quality products services, research, and services.
Boster is a global leader in the development of research antibodies and ELISA kits, Boster is dedicated to supporting the research of its customers and staying at the forefront of research. Boster's quality standards are unmatched as their reagents and kits made in-house. To ensure the highest quality and efficiency, these reagents come subject to rigorous monitoring. The Boster Bio team also provides expert consulting servicesthat allow researchers to use their products without the hassle of purchasing the reagents and kits from various sources.
Boster is a top-rated company in terms of safety and quality with numerous awards for its products. Boster is ISO 9001 certified and continues to strive for excellence in everything it does. They have set the industry standard in terms of quality for more than two decades and are committed to providing the most superior products and services for its customers. These awards are not just awarded to top scientists as well as acknowledged for their commitment to quality.
Boster Bio's policy on returns for the HPSE marker is a two-step. When you receive the product, inspect it carefully, and notify Boster Biological Technology of any defects or shortages within the first 12 months. Boster Bio will issue a replacement or refund for the defective item or whichever option you prefer. If you wish, the company will also pay for shipping costs to ship the product that is defective back.
In terms of returns, Boster Bio is very flexible. Customers are able to return the HPSE marker within 10 business days from the date of receipt. This policy is in force to ensure satisfaction of customers. Boster Bio is not responsible for returned products. If you're not happy with your HPSE marker, you can return it to Boster Bio for an entire refund. The company will issue a return authorization number. When you return the product, you'll need to pay a 25% restocking fee.
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PMID: 10405343 by Kussie P.H., et al. Cloning and functional expression of a human heparanase gene.
PMID: 10446189 by Toyoshima M., et al. Human heparanase. Purification, characterization, cloning, and expression.
*More publications can be found for each product on its corresponding product page