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- Table of Contents
Insulin-degrading enzyme Antibodies
AND IDE ELISA kits, Insulin-degrading enzyme Proteins
Many biological assays use antibodies to detect Insulin-degrading enzyme, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Insulin-degrading enzyme in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Insulin-degrading enzyme antibodies...
Designing a Western blot for Insulin-degrading enzyme? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IDE Western Blot GuideIDE Infographic by Boster Bio
All IDE Products
Product
Figures
Specificity
Applications
Price
Human S100A12/En Rage ELISA Kit PicoKine®
3 Citations
Human
ELISA
$450
Cat # EK1169
96 wells/kit, with removable strips.
Cat # EK1169
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, ICC, WB
$370
Cat # A01358-2
100 μg/vial
Cat # A01358-2
100 μg/vial
Human
IHC, WB
$449
Cat # M00254-5
100uL
Cat # M00254-5
100uL
Human
Flow Cytometry, IHC, WB
$370
Cat # M00377-2
100 μg/vial
Cat # M00377-2
100 μg/vial
Human, Rat
IHC, WB
$370
Cat # M00389-2
100 μg/vial
Cat # M00389-2
100 μg/vial
Enzyme Activity, SDS-PAGE
$293
Cat # PROTP14735-1
Starting from 10ug
Cat # PROTP14735-1
Starting from 10ug
IDE Overview
Facts about Insulin-degrading enzyme.
Insulin-degrading enzyme (IDE)
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP.
May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. .
Gene Information
| Human | |
|---|---|
| Gene Name: | IDE |
| Uniprot: | P14735 |
| Entrez: | 3416 |
Family
| Belongs to: |
|---|
| peptidase M16 family |
Alternative Names
Abeta-degrading protease; EC 3.4.24; EC 3.4.24.56; FLJ35968; IDE; INSDEGM; Insulin protease; Insulinase; insulin-degrading enzyme; Insulysin
Molecular Weight
Mass (kDA):
117.968 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q23.33 |
| Sequence: | 10; NC_000010.11 (92451684..92574095, complement) |
Subcellular Localizations
Cytoplasm, cytosol. Cell membrane. Secreted. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
Diseases
- Alzheimer's Disease
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Resistance
- Neoplasms
- Dementia
- Abnormal Degeneration
- Pain
- Senile Plaques
- Plaque, Amyloid
- Hyperinsulinism
- Dental Plaque
- Impaired Glucose Tolerance
Interacting Proteins
- APP
- CCL3
- GCG
- IAPP
- INS
Pathways
- Pathogenesis
- Proteolysis
- Localization
- Secretion
- Aging
- Insulin Secretion
- Transport
- Translation
- Endocytosis
- Cognition
- Cell Proliferation
- Glucose Homeostasis
- Cellular Localization
PTMs
- Cleavage
- Phosphorylation
- Oxidation
- Nitrosylation
- Prenylation
- Iodination
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IDE
bosterbio.com/bosterbio-gene-info-cards/IDE
References
PMID: 3059494 by Affholter J.A., et al. Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III.
PMID: 2293021 by Affholter J.A., et al. Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.
19 Publications of Boster Insulin-degrading enzyme Antibodies & ELISA Kits
- PubMed ID: 10.2147/CIA.S309082, Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cogni...
- PubMed ID: -, Efficacy of EP chemotherapy followed by IP chemotherapy combined with radiothera...
- PubMed ID: 34021822, Li X,Lv J,Hou L,Guo X. Circ_0001955 Acts as a miR-646 Sponge to Promote the Prol...
- PubMed ID: 33976542, Liu T,Yin C,Li Y,Gao F,Yu L,Wang Z,Wang Q.Effects of Transcutaneous Electrical A...
- PubMed ID: 32194806, Fan R,Wang H,Zhang L,Ma T,Tian Y,Li H.Nanocrystallized Oleanolic Acid Better Inh...
- PubMed ID: -, Xiaozhu Tian,Rong Li,Yiming Jiang,Fei Zhao,Zhengsheng Yu,Yiqing Wang,Zixing Dong...
- PubMed ID: 32158357, Yang Z,Zhang J,Lu D,Sun Y, Zhao X,Wang X,Zhou W,He Q,Jiang Z.Hsa_circ_0137008 su...
- PubMed ID: 33335571, Han Y,Chen M,Wang H. Production of a SCID mouse model of medulloblastoma to expl...
- PubMed ID: 20970817, A study on expression of FSH and its effects on the secretion of insulin and glu...
- PubMed ID: 26397136, KDM4B and KDM4A promote endometrial cancer progression by regulating androgen re...
- PubMed ID: 29069746, WX-132-18B, a novel microtubule inhibitor, exhibits promising anti-tumor effects
- PubMed ID: 26921196, Nek7 is overexpressed in hepatocellular carcinoma and promotes hepatocellular ca...
- PubMed ID: 23554729, Soy isoflavone extracts stimulate the growth of nude mouse xenografts bearing es...
- PubMed ID: 28848999, Pan Z, Tian Y, Zhang B, Zhang X, Shi H, Liang Z, Wu P, Li R, You B, Yang L, Mao ...
- PubMed ID: 25888093, Cheng Z, Wang Hz, Li X, Wu Z, Han Y, Li Y, Chen G, Xie X, Huang Y, Du Z, Zhou Y....
- PubMed ID: 18161927, Zhao Xy, Chen L, Li Yh, Xu Q. World J Gastroenterol. 2007 Dec 28;13(48):6558-61....
- PubMed ID: 25662849, Li Xt, Wang Hz, Wu Zw, Yang Tq, Zhao Zh, Chen Gl, Xie Xs, Li B, Wei Yx, Huang Yl...
- PubMed ID: 21660959, Yi M, Yang J, Chen X, Li J, Li X, Wang L, Tan Y, Xiong W, Zhou M, Mccarthy Jb, L...
- PubMed ID: 23588620, Yuan Y, Zhang J, Cai L, Ding C, Wang X, Chen H, Wang X, Yan J, Lu J. Oncol Rep. ...
*More publications can be found for each product on its corresponding product page