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Insulin-degrading enzyme Antibodies
AND IDE ELISA kits, Insulin-degrading enzyme Proteins
Many biological assays use antibodies to detect Insulin-degrading enzyme, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Insulin-degrading enzyme in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Insulin-degrading enzyme antibodies...
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IDE Infographic by Boster Bio
All IDE Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, ICC, WB
$370
Cat # A01358-2
100 μg/vial
Cat # A01358-2
100 μg/vial
IDE Overview
Facts about Insulin-degrading enzyme.
Insulin-degrading enzyme (IDE)
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP.
May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. .
Gene Information
| Human | |
|---|---|
| Gene Name: | IDE |
| Uniprot: | P14735 |
| Entrez: | 3416 |
Family
| Belongs to: |
|---|
| peptidase M16 family |
Alternative Names
Abeta-degrading protease; EC 3.4.24; EC 3.4.24.56; FLJ35968; IDE; INSDEGM; Insulin protease; Insulinase; insulin-degrading enzyme; Insulysin
Molecular Weight
Mass (kDA):
117.968 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q23.33 |
| Sequence: | 10; NC_000010.11 (92451684..92574095, complement) |
Subcellular Localizations
Cytoplasm, cytosol. Cell membrane. Secreted. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
Diseases
- Alzheimer's Disease
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Resistance
- Neoplasms
- Dementia
- Abnormal Degeneration
- Pain
- Senile Plaques
- Plaque, Amyloid
- Hyperinsulinism
- Dental Plaque
- Impaired Glucose Tolerance
Interacting Proteins
- APP
- CCL3
- GCG
- IAPP
- INS
Pathways
- Pathogenesis
- Proteolysis
- Localization
- Secretion
- Aging
- Insulin Secretion
- Transport
- Translation
- Endocytosis
- Cognition
- Cell Proliferation
- Glucose Homeostasis
- Cellular Localization
PTMs
- Cleavage
- Phosphorylation
- Oxidation
- Nitrosylation
- Prenylation
- Iodination
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IDE
bosterbio.com/bosterbio-gene-info-cards/IDE
References
PMID: 3059494 by Affholter J.A., et al. Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III.
PMID: 2293021 by Affholter J.A., et al. Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.
1 Publications of Boster Insulin-degrading enzyme Antibodies & ELISA Kits
- PubMed ID: 20970817, A study on expression of FSH and its effects on the secretion of insulin and glu...
*More publications can be found for each product on its corresponding product page