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- Table of Contents
IDH3A Antibodies
AND IDH3A ELISA kits, IDH3A Proteins
Many biological assays use antibodies to detect IDH3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IDH3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IDH3A antibodies...
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IDH3A Infographic by Boster Bio
All IDH3A Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M09544
100 µl
Cat # M09544
100 µl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A09544-3
100 µg/vial
Cat # A09544-3
100 µg/vial
IDH3A Overview
Facts about Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial.
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3A)
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full action of the heterotetramer (containing two subunits of IDH3A, among IDH3B and among IDH3G) requires the assembly and cooperative function of both heterodimers.
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Gene Information
| Human | |
|---|---|
| Gene Name: | IDH3A |
| Uniprot: | P50213 |
| Entrez: | 3419 |
Family
| Belongs to: |
|---|
| isocitrate and isopropylmalate dehydrogenases family |
Alternative Names
EC 1.1.1; EC 1.1.1.41; H-IDH alpha; isocitrate dehydrogenase (NAD+) alpha chain; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; isocitrate dehydrogenase 3 (NAD+) alpha; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; NAD(H)-specific isocitrate dehydrogenase alpha subunit; NAD+-specific ICDH
Molecular Weight
Mass (kDA):
39.592 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q25.1 |
| Sequence: | 15; NC_000015.10 (78149362..78171945) |
Subcellular Localizations
Mitochondrion.
Diseases
- Disease Of Adrenal Medulla
- Malignant Neoplasm Of Breast
- Neurodegenerative Disorders
- Lung Diseases
- Kidney Failure
- Parkinson Disease
- Chronic Obstructive Airway Disease
- Lung Diseases, Obstructive
- Cataract
- Severe Sepsis
Pathways
- Oxidative Phosphorylation
- Transport
- Aging
- Fatty Acid Oxidation
- Glycolysis
- Secretion
PTMs
- Phosphorylation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IDH3A
bosterbio.com/bosterbio-gene-info-cards/IDH3A
References
PMID: 7755589 by Kim Y.O., et al. Characterization of a cDNA clone for human NAD(+)-specific isocitrate dehydrogenase alpha-subunit and structural comparison with its isoenzymes from different species.
PMID: 28139779 by Ma T., et al. The beta and gamma subunits play distinct functional roles in the alpha2betagamma heterotetramer of human NAD-dependent isocitrate dehydrogenase.