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1 Citations 4 Q&As
Facts about Immunoglobulin heavy constant epsilon.
In the recognition phase of humoral immunity, the membrane-bound immunoglobulins function as receptors that, upon binding of a specific antigen, activate the clonal growth and differentiation of B lymphocytes to immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector stage of humoral immunity, which causes the elimination of bound antigens (PubMed:22158414, PubMed:20176268).
Human | |
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Gene Name: | IGHE |
Uniprot: | P01854 |
Entrez: | 3497 |
Belongs to: |
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No superfamily |
IgE; immunoglobulin heavy constant epsilon
Mass (kDA):
47.019 kDA
Human | |
---|---|
Location: | 14q32.33 |
Sequence: | 14; NC_000014.9 (105600066..105601727, complement) |
Secreted. Cell membrane.
Research has many applications for the IGHE indicator. It has been used to determine if a specific protein is present in a cell. In addition, it can be used to evaluate the cell's ability to absorb a particular molecule. IGHE is a great candidate for immunology and cell biology research. The IGHE protein is a marker that is widely used to determine if a cell is healthy.
Flow Cytometry is an effective tool for cell biology research. It is used for many applications in immunology. Flow Cytometry has seen rapid advances over the last 30 year, allowing for unprecedented detail when studying the immune system and cell biology. Flow cytometry using the IGHE marker can be used to identify and quantify the circulating immune cells and detect a wide variety of tumor-associated inflammatory disease.
Before you can perform flow cytometry, you must prepare the sample. The sample is then made into a suspension using either cell culture, blood or tissue disaggregation. The samples are then separated into tubes for staining. The unstained cells are retained for use as controls. Rest of the samples are stained using fluorescent probes or dyes that stain cell components. To achieve this, the cells must first be fixed in formalin buffer and then permeabilized using a permeabilizing agent. To get statistics, flow cytometry data can be processed.
Flow cytometry is a useful tool for medical practitioners to monitor immune cell activity, as well as assess the effectiveness of treatment and predict relapse. Flow Cytometry can also help healthcare professionals identify cancer cells and other abnormalities in body fluids. It also allows researchers to gain valuable insights into the complexities of certain conditions. Flow Cytometry is usually performed by pathologists and lab technicians. It requires a sample from blood, bone marrow or tissue.
Flowcytometry uses fluorescent markers for measuring single cell density. The process involves suspending single cells in a stream and then analyzing the fluorescence. The result allows researchers to quantify six different properties or components of a sample. Flow Cytometry can analyze more that ten thousand cells in a matter of minutes. Flow cytometry results are analyzed by a computer.
IGHE is a fluorescent proteins that is produced in human blood cell. Flow cytometry uses fluorescent ligand IGHE, which is a fluorescent protein that has been labelled. This marker is used to detect the cellular function of a cell. The IGHE marker is an excellent choice for this application. It is sensitive to DNA fragments and can be difficult to detect in high-throughput flowcytometry.
Flow cytometry can be used for immunophenotyping or cell sorting. This type of flow cytometry analyses individual cells and particles as they move past a stationary detector. Multiple fluorescent markers, such as fluorescent proteins, can be used to identify different types of cells. Flow cytometry has become a popular tool for identifying subsets within the immune system.
There are many uses for the IGHE marker in immunology. It contributes to immunoglobulin-receptor binding activity. It is located in the extracellular area and is part secreted Dimeric IgA complex. It is also involved in the inflammatory reaction pathway.
PMID: 6288268 by Max E.E., et al. Duplication and deletion in the human immunoglobulin epsilon genes.
PMID: 6234164 by Flanagan J.G., et al. The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.
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