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Interleukin-17 receptor D Antibodies
AND IL17RD ELISA kits, Interleukin-17 receptor D Proteins
Many biological assays use antibodies to detect Interleukin-17 receptor D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Interleukin-17 receptor D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Interleukin-17 receptor D antibodies...
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IL17RD Infographic by Boster Bio
All IL17RD Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK2083
96 wells/kit, with removable strips.
Cat # EK2083
96 wells/kit, with removable strips.
IL17RD Overview
Facts about Interleukin-17 receptor D.
Interleukin-17 receptor D (IL17RD)
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation.
Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and can be involved in apoptosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | IL17RD |
| Uniprot: | Q8NFM7 |
| Entrez: | 54756 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ35755; IL-17 RD; IL17RD; IL-17RD; IL-17RDIL-17 receptor D; IL17Rhom; IL17RLM; IL17RLMDKFZp434N1928; interleukin 17 receptor D; interleukin-17 receptor D; Interleukin-17 receptor-like protein; MGC133309; Sef homolog; SEF; SEFhSef
Molecular Weight
Mass (kDA):
82.411 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p14.3 |
| Sequence: | 3; NC_000003.12 (57089982..57170317, complement) |
Tissue Specificity
Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex. Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells.
Subcellular Localizations
Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.; [Isoform 4]: Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Prostatic Neoplasms
- Inflammation
- Carcinogenesis
- Carcinoma
- Malignant Neoplasm Of Prostate
- Autoimmune Reaction
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Ovarian Neoplasm
- Autoimmune Diseases
- Tumor Progression
Pathways
- Cell Proliferation
- Pathogenesis
- Localization
- Cell Differentiation
- Cell Migration
- Cell Death
- Cellular Localization
- Fibroblast Proliferation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL17RD
bosterbio.com/bosterbio-gene-info-cards/IL17RD
References
PMID: 12958313 by Xiong S.Q., et al. hSef inhibits PC-12 cell differentiation by interfering with Ras- mitogen-activated protein kinase MAPK signaling.
PMID: 14742870 by Preger E., et al. Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity.