Interleukin-1 receptor accessory protein (IL1RAP)

Coreceptor for IL1RL2 from the IL-36 signaling system (By similarity). Coreceptor with IL1R1 from the IL-1 signaling system.

Associates with IL1R1 jumped to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling requires the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of their receptor/coreceptor subunits.