Integrin alpha-2 (ITGA2)

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It admits the proline-hydroxylated sequence G-F-P-G-E-R in hydration.

It's responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. .