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- Table of Contents
Intersectin-1 Antibodies
AND ITSN1 ELISA kits, Intersectin-1 Proteins
Many biological assays use antibodies to detect Intersectin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Intersectin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Intersectin-1 antibodies...
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ITSN1 Infographic by Boster Bio
All ITSN1 Products
Product
Figures
Specificity
Applications
Price
Human
$960
Cat # LS006453
20 µg, 100 µg
Cat # LS006453
20 µg, 100 µg
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03616-1
100 µg/vial
Cat # A03616-1
100 µg/vial
ITSN1 Overview
Facts about Intersectin-1.
Intersectin-1 (ITSN1)
Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide direct connection between the endocytic membrane traffic and the actin assembly machinery.
May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve affiliation with DAB2.
Gene Information
| Human | |
|---|---|
| Gene Name: | ITSN1 |
| Uniprot: | Q15811 |
| Entrez: | 6453 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
11; intersectin 1 (SH3 domain protein); intersectin short variant 12; intersectin-1; ITSN; SH3 domain protein-1A; SH3 domain-containing protein 1A; Src homology 3 domain-containing protein
Molecular Weight
Mass (kDA):
195.422 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.11 |
| Sequence: | 21; NC_000021.9 (33642452..33899861) |
Tissue Specificity
Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord.
Subcellular Localizations
Endomembrane system. Cell junction, synapse, synaptosome. Cell projection, lamellipodium. Cell membrane. Membrane, clathrin-coated pit. Recycling endosome. Endosome. Cytoplasmic vesicle. Colocalizes with SGIP1 at the plasma membrane in structures corresponding most probably to clathrin-coated pits (PubMed:20946875). Colocalizes with RAB13 on cytoplasmic vesicles that are most likely recycling endosomes (PubMed:29030480).; [Isoform 2]: Cytoplasm. Endomembrane system. Nucleus envelope. Shuttles between the cytoplasm and nucleus in an XPO1/CRM1-dependent manner.; [Isoform 5]: Endomembrane system.
Diseases
- Down Syndrome
- Infection By Cryptococcus Neoformans
- Nervousness
- Alzheimer's Disease
- Malignant Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Brain Neoplasms
- Glioma
- Neurodegenerative Disorders
- Glioblastoma
- Malignant Glioma
Interacting Proteins
- CBL
- DISC1
- DNM2
- EPS15
- Fcho2
- INPPL1
- Sh3kbp1
Pathways
- Endocytosis
- Clathrin-mediated Endocytosis
- Exocytosis
- Pathogenesis
- Transport
- Virulence
- Cytokinesis
- Intracellular Transport
- Metaphase
- Rna Interference
- Mitochondrial Outer Membrane Permeabilization
- Tissue Development
- Cytoskeleton Organization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITSN1
bosterbio.com/bosterbio-gene-info-cards/ITSN1
References
PMID: 9799604 by Guipponi M., et al. Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon.
PMID: 10482960 by Pucharcos C., et al. Alu-splice cloning of human intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome.