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1 Citations 6 Q&As
Facts about Interleukin-15 receptor subunit alpha.
Expression of distinct isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 don't bind IL15.
Human | |
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Gene Name: | IL15RA |
Uniprot: | Q13261 |
Entrez: | 3601 |
Belongs to: |
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No superfamily |
CD215 antigen; CD215; IL15 R alpha; IL-15 R alpha; IL-15 receptor subunit alpha; IL-15R alpha; IL15RA; IL-15Ra; IL-15R-alpha; interleukin 15 receptor, alpha; interleukin-15 receptor subunit alpha; MGC104179
Mass (kDA):
28.233 kDA
Human | |
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Location: | 10p15.1 |
Sequence: | 10; NC_000010.11 (5948897..5978741, complement) |
Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
Membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Cell surface. Mainly found associated with the nuclear membrane.; [Isoform 5]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; [Isoform 6]: End
In this article, we'll provide the best Boster Bio tips and tricks, as well as troubleshooting guides for the marker IL15RA. This guide will assist you in maximizing your Boster Bio's potential. Continue reading to find out more. Be aware that regardless of what the purpose of your application you should know that your Boster Bio will always provide you with the best results.
If you are planning to conduct IHC analysis for the marker IL15RA, be aware that it's difficult to attain outstanding results. Boster Bio has a wide selection of secondary antibodies, isotype control, and detection systems that can be used to detect this marker. Listed below are some tips and tricks that can simplify the process for you. Learn more to enhance your results.
Boster Bio troubleshooting guidelines can help you avoid many kinds of errors in your research. These guides provide a step-by-step procedure, a diagram of the workflow and recommended chemicals. Like all tests, IHC optimization is critical to achieving reliable results. This guide provides suggestions on how to extract, fix, and embed antigens, as well as best practices in preserving samples to be used in IHC analysis. The guides provide detailed instructions for different types of preserved tissues that are essential to high-quality staining.
The IL15RA gene encodes a transcriptional factor essential for immune function. Boster Bio has developed an IL-15RA antigen that reacts with both Human and Rat cytotoxic T cells. The antibody is liquid in PBS and can be stored at -20 deg C for one year or 4 deg C for up to a month. It can be used by scientists across the globe.
It is a crucial cytokine that is produced by memory cells of the CD8+ and natural killer cells. Interleukin-15, in spite of its limited capacity and short half life in the body, is a promising molecule to treat various cancers. There are several recombinant IL-15 agonists are being studied as monotherapy agents as well as combinations of T cells that are cytotoxic.
PMID: 8530383 by Anderson D.M., et al. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes.
PMID: 9110174 by Yu W., et al. Large-scale concatenation cDNA sequencing.
*More publications can be found for each product on its corresponding product page