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- Table of Contents
Facts about Junctional adhesion molecule-like.
Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
Human | |
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Gene Name: | JAML |
Uniprot: | Q86YT9 |
Entrez: | 120425 |
Belongs to: |
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immunoglobulin superfamily |
adhesion molecule, interacts with CXADR antigen 1; AMICA; AMICA1; CREA7-1; Gm638; JAML
Mass (kDA):
44.339 kDA
Human | |
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Location: | 11q23.3 |
Sequence: | 11; NC_000011.10 (118193725..118225089, complement) |
Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).
Cell membrane; Single-pass type I membrane protein. Cell junction. Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
PMID: 12869515 by Moog-Lutz C., et al. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells.
PMID: 15800062 by Zen K., et al. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils.