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Junctophilin-2 Antibodies
AND JPH2 ELISA kits, Junctophilin-2 Proteins
Many biological assays use antibodies to detect Junctophilin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Junctophilin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Junctophilin-2 antibodies...
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JPH2 Infographic by Boster Bio
All JPH2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, WB
$523
Cat # M06785
100 µl
Cat # M06785
100 µl
Human
$960
Cat # LS057158
20 µg, 100 µg
Cat # LS057158
20 µg, 100 µg
JPH2 Overview
Facts about Junctophilin-2.
Junctophilin-2 (JPH2)
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
JPH2 is vital for proper intracellular Ca(2+) signaling in cardiac myocytes through its participation in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.
Gene Information
| Human | |
|---|---|
| Gene Name: | JPH2 |
| Uniprot: | Q9BR39 |
| Entrez: | 57158 |
Family
| Belongs to: |
|---|
| junctophilin family |
Alternative Names
JP2; junctophilin 2; junctophilin type 2; junctophilin-2
Molecular Weight
Mass (kDA):
74.222 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.12 |
| Sequence: | 20; NC_000020.11 (44106590..44187946, complement) |
Tissue Specificity
Specifically expressed in skeletal muscle and heart.
Subcellular Localizations
[Junctophilin-2]: Cell membrane; Peripheral membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands.; [Junctophilin-2 N-terminal fragment]: Nucleus. Accumulates in the nucleus of stressed hearts.
Diseases
- Hypertrophic Cardiomyopathy
- Cardiomyopathies
- Hypertrophy
- Heart Diseases
- Heart Failure
- Cardiac Hypertrophy
- Cardiac Arrest
Pathways
- Pathogenesis
- Rna Interference
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JPH2
bosterbio.com/bosterbio-gene-info-cards/JPH2
References
PMID: 10891348 by Nishi M., et al. Characterization of human junctophilin subtype genes.
PMID: 20095964 by Woo J.S., et al. S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle.