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- Table of Contents
KDELR1 Antibodies
AND KDELR1 ELISA kits, KDELR1 Proteins
Many biological assays use antibodies to detect KDELR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDELR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDELR1 antibodies...
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KDELR1 Infographic by Boster Bio
All KDELR1 Products
Product
Figures
Specificity
Applications
Price
Human
$628
Cat # LS010945
20 µg, 100 µg
Cat # LS010945
20 µg, 100 µg
KDELR1 Overview
Facts about ER lumen protein-retaining receptor 1.
ER lumen protein-retaining receptor 1 (KDELR1)
Required for the retention of luminal endoplasmic reticulum resident proteins through vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif.
COPI-coated transport intermediates, either in the form of round vesicles or as tubular procedures, mediate retrograde visitors of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi.
Gene Information
| Human | |
|---|---|
| Gene Name: | KDELR1 |
| Uniprot: | P24390 |
| Entrez: | 10945 |
Family
| Belongs to: |
|---|
| ERD2 family |
Alternative Names
ER lumen protein retaining receptor 1; ERD2; ERD2.1KDEL receptor 1; HDEL; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; PM23; Putative MAPK-activating protein PM23
Molecular Weight
Mass (kDA):
24.542 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (48382575..48391551, complement) |
Subcellular Localizations
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.
Diseases
- Physiological Stress
- Infective Disorder
- Adenocarcinoma
- Cell Transformation, Neoplastic
- Pelizaeus-merzbacher Disease
- Gastritis
- Endoplasmic Reticulum Stress
- Insulin Resistance
- Epilepsy
- Malignant Neoplasms
- Diabetes Mellitus, Experimental
Pathways
- Transport
- Localization
- Secretory Pathway
- Pathogenesis
- Secretion
- Cell Activation
- Golgi Localization
- Cell Proliferation
- Circadian Rhythm
- Mitosis
- Glycosylation
- Oxidative Phosphorylation
- Microtubule-based Transport
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDELR1
bosterbio.com/bosterbio-gene-info-cards/KDELR1
References
PMID: 2172835 by Lewis M.J., et al. A human homologue of the yeast HDEL receptor.
PMID: 12761501 by Matsuda A., et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.