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Kinesin-1 heavy chain Antibodies
AND KIF5B ELISA kits, Kinesin-1 heavy chain Proteins
Many biological assays use antibodies to detect Kinesin-1 heavy chain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kinesin-1 heavy chain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kinesin-1 heavy chain antibodies...
Designing a Western blot for Kinesin-1 heavy chain? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KIF5B Western Blot GuideDesigning an IHC experiment for Kinesin-1 heavy chain? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KIF5B IHC GuideKIF5B Infographic by Boster Bio
All KIF5B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M01934
100 μl/vial
Cat # M01934
100 μl/vial
KIF5B Overview
Facts about Kinesin-1 heavy chain.
Kinesin-1 heavy chain (KIF5B)
Microtubule-dependent motor needed for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells at a ZFYVE27-dependent way (By similarity).
Regulates centrosome and nuclear positioning during mitotic entry. During the G2 stage of the cell cycle at a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).
Gene Information
| Human | |
|---|---|
| Gene Name: | KIF5B |
| Uniprot: | P33176 |
| Entrez: | 3799 |
Family
| Belongs to: |
|---|
| TRAFAC class myosin-kinesin ATPase superfamily |
Alternative Names
Conventional kinesin heavy chain; kinesin family member 5B; kinesin-1 heavy chain; KNS1kinesin 1 (110-120kD); KNSKINH; Ubiquitous kinesin heavy chain; UKHCkinesin heavy chain
Molecular Weight
Mass (kDA):
109.685 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p11.22 |
| Sequence: | 10; NC_000010.11 (32009015..32056425, complement) |
Subcellular Localizations
Cytoplasm, cytoskeleton. Uniformly distributed between soma and neurites in hippocampal neurons.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Adenocarcinoma
- Non-small Cell Lung Carcinoma
- Neoplasms
- Adenocarcinoma Of Lung (disorder)
- Lymphoma
- Anaplastic Lymphoma
- Carcinoma
- Cell Transformation, Neoplastic
- Nervousness
- Cell Invasion
Interacting Proteins
- FYCO1
- Syne4
- YWHAZ
Pathways
- Transport
- Localization
- Secretion
- Synaptic Transmission
- Exocytosis
- Pathogenesis
- Intracellular Transport
- Insulin Secretion
- Cell Migration
- Membrane Fusion
- Protein Transport
- Neurogenesis
- Translation
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KIF5B
bosterbio.com/bosterbio-gene-info-cards/KIF5B
References
PMID: 1607388 by Navone F., et al. Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells.
PMID: 15459722 by Su Q., et al. Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons.