KMT2C Antibodies

AND KMT2C ELISA kits, KMT2C Proteins

Many biological assays use antibodies to detect KMT2C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KMT2C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KMT2C antibodies...

We validate the specificity of these antibodies to KMT2C by testing them on tissues known to express KMT2C positively and negatively. Browse below to find the KMT2C antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KMT2C Infographic by Boster Bio

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Anti-KMT2C Antibody (Monoclonal, 32K33)

Human, Mouse, Rat

$370
Cat # M02023
100 μl/vial

KMT2C Overview

Facts about Histone-lysine N-methyltransferase 2C.

Histone-lysine N-methyltransferase 2C (KMT2C)

Histone methyltransferase. Methylates 'Lys-4' of histone H3.

H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.

Gene Information

Human
Gene Name:	KMT2C
Uniprot:	Q8NEZ4
Entrez:	58508

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

ALR-like protein; DKFZp686C08112; EC 2.1.1.43; FLJ12625; HALRMGC119851; histone-lysine N-methyltransferase MLL3; histone-lysine N-methyltransferase, H3 lysine-4 specific; Homologous to ALR protein; KIAA1506FLJ38309; KMT2C; KMT2CMGC119852; Lysine N-methyltransferase 2C; MGC119853; myeloid/lymphoid or mixed-lineage leukemia 3; Myeloid/lymphoid or mixed-lineage leukemia protein 3

Molecular Weight

Mass (kDA):
541.37 kDA

Genomic Context


Human

Location:	7q36.1
Sequence:	7; NC_000007.14 (152134925..152436642, complement)

Tissue Specificity

Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Leukemia
Neoplasms
Colorectal Cancer
Carcinoma
Colorectal Neoplasms
Cell Transformation, Neoplastic
Adenocarcinoma
Microsatellite Instability
Mutation, Out-of-frame
Malignant Neoplasm Of Breast
Myeloid Leukemia
Mammary Neoplasms

Liver Neoplasms
Carcinogenesis
Pancreatic Neoplasm
Malignant Neoplasm Of Pancreas
Leukemogenesis
Multiple Endocrine Neoplasia Type 1
Melanoma

Interacting Proteins

NCOA6
WDR5

Pathways

Methylation
Chromatin Remodeling
Cell Adhesion
Dna Recombination
Regulation Of Gene Expression
Mrna Processing
Histone Methylation
Receptor Transactivation
Demethylation
Histone Modification
Mammary Gland Development
V(d)j Recombination
Inflammatory Response

Embryo Development
Translation
Axon Guidance
Cell Cycle
Cognition
Chromatin Modification
Cell Proliferation

PTMs

Methylation
Demethylation

Acetylation
Cleavage

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KMT2C

References

PMID: 11891048 by Ruault M., et al. MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.

PMID: 11718452 by Tan Y.C., et al. Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects.