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- Table of Contents
Facts about Phosphatidate phosphatase LPIN2.
Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity). .
Human | |
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Gene Name: | LPIN2 |
Uniprot: | Q92539 |
Entrez: | 9663 |
Belongs to: |
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lipin family |
EC 3.1.3.4; KIAA0249lipin-2; Lipin 2; Lipin-2; LPIN2; phosphatidate phosphatase LPIN2
Mass (kDA):
99.399 kDA
Human | |
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Location: | 18p11.31 |
Sequence: | 18; NC_000018.10 (2916994..3013315, complement) |
Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane. Translocates to endoplasmic reticulum membrane with increasing levels of oleate.
PMID: 17158099 by Donkor J., et al. Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
PMID: 15994876 by Ferguson P.J., et al. Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome).