LRRC8D Antibodies

AND LRRC8D ELISA kits, LRRC8D Proteins

Many biological assays use antibodies to detect LRRC8D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRRC8D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRRC8D antibodies...

We validate the specificity of these antibodies to LRRC8D by testing them on tissues known to express LRRC8D positively and negatively. Browse below to find the LRRC8D antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LRRC8D Infographic by Boster Bio

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LRRC8D (NM_001134479) Human Recombinant Protein

Coomassie blue staining of purified LRRC8D protein

$1249
Cat # PROTQ7L1W4
20 µg

LRRC8D Overview

Facts about Volume-regulated anion channel subunit LRRC8D.

LRRC8D 3D structure. Source: alphafold

Volume-regulated anion channel subunit LRRC8D (LRRC8D)

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC station ), an anion channel necessary to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731).

Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A and at least one other relative (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics are based on the exact subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731).

Gene Information

Human
Gene Name:	LRRC8D
Uniprot:	Q7L1W4
Entrez:	55144

Family

Belongs to:

LRRC8 family

Alternative Names

Volume-regulated anion channel subunit LRRC8D

Molecular Weight

Mass (kDA):
98.201 kDA

Genomic Context


Human

Location:	1p22.2
Sequence:	1; NC_000001.11 (89821014..89936611)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029).

Interacting Proteins

LRRC8A

PTMs

Disulfide bond

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRRC8D

References

PMID: 22532330 by Abascal F., et al. LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.

PMID: 24782309 by Lee C.C., et al. The protein synthesis inhibitor blasticidin S enters mammalian cells via leucine-rich repeat-containing protein 8D.